Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.56 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.53 |
| ▸ | MEN1 | O00255 | 6/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.53 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.53 |
| ▸ | BCL2 | P10415 | 5/20 | 0.52 |
| ▸ | BCL2L2 | Q92843 | 5/20 | 0.52 |
| ▸ | BAD | Q92934 | 5/20 | 0.52 |
| ▸ | POLB | P06746 | 4/20 | 0.52 |
| ▸ | MME | P08473 | 2/20 | 0.52 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.52 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.52 |
| ▸ | CTSL | P07711 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | CRHBP | P24387 | 1/20 | 0.50 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19425501 | 0.73 | DUSP3 (0.72) | MAPTPTPN22ALDH1A1MEN1KMT2A | |
| SCHEMBL19430434 | 0.73 | MAPT (1.00) | MAPTALDH1A1MEN1KMT2ADUSP3 | |
| SCHEMBL19425333 | 0.71 | MAPT (0.61) | MAPTPTPN22ALDH1A1MEN1KMT2A | |
| SCHEMBL19425506 | 0.71 | DUSP3 (0.71) | MAPTPTPN22ALDH1A1MEN1KMT2A | |
| SCHEMBL13846498 | 0.70 | MAPT (0.87) | MAPTALDH1A1MEN1KMT2ABCL2 | |
| SCHEMBL13894970 | 0.69 | DUSP3 (0.71) | MAPTPTPN22ALDH1A1MEN1KMT2A | |
| SCHEMBL14680251 | 0.68 | MAPT (0.78) | MAPTALDH1A1MEN1KMT2ADUSP3 | |
| SCHEMBL3638794 | 0.68 | MAPT (0.82) | MAPTALDH1A1MEN1KMT2ADUSP3 | |
| SCHEMBL3638795 | 0.68 | MAPT (0.82) | MAPTALDH1A1MEN1KMT2ADUSP3 | |
| SCHEMBL19430430 | 0.68 | MAPT (0.82) | MAPTALDH1A1MEN1KMT2ADUSP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10000511-B2 | Small molecules for the modulation of MCL-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2018-06-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10000511-B2 | Small molecules for the modulation of MCL-1 and methods of modulating cell death, cell division, cell differentiation and methods of treating disorders | MCL1, BCL2, BCL2L1 | MAPT 3689/4885PTPN22 3305/4885ALDH1A1 2862/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.