Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 9/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.42 |
| ▸ | SCN4A | P35499 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | ILK | Q13418 | 1/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.38 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | MPL | P40238 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30129625 | 1.00 | TRPM5 (0.46) | TRPM5EPHX2SCN4ABACE1METAP2 | |
| SCHEMBL12705884 | 0.81 | TRPM5 (0.39) | TRPM5TRPA1 | |
| SCHEMBL18608517 | 0.72 | KIF11 (0.43) | TRPM5KDM4E | |
| SCHEMBL1144862 | 0.69 | TRPM5 (0.43) | TRPM5METAP2KDM4ETRPA1 | |
| SCHEMBL7378448 | 0.69 | TRPM5 (0.40) | TRPM5TRPA1 | |
| SCHEMBL7588186 | 0.69 | BACE1 (0.56) | EPHX2SCN4ABACE1METAP2PTPN5 | |
| SCHEMBL29379298 | 0.68 | PTPRC (0.62) | EPHX2SCN4ABACE1METAP2DYRK1A | |
| SCHEMBL826881 | 0.68 | PTPRC (0.62) | EPHX2SCN4ABACE1METAP2DYRK1A | |
| SCHEMBL27920310 | 0.67 | BACE1 (0.50) | EPHX2SCN4ABACE1METAP2PTPN5 | |
| SCHEMBL18002994 | 0.67 | EPHX2 (0.43) | EPHX2SCN4ABACE1METAP2ILK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113214182-A | Benzisothiazole compound and preparation method thereof | 佛山湘潭大学绿色智造研究院 | 2021-08-06 | — | — | CN | claimed |
| CN-113214182-B | Benzisothiazole compound and preparation method thereof | 佛山湘潭大学绿色智造研究院 | 2022-12-23 | — | — | CN | disclosed |
| CN-113214182-A | Benzisothiazole compound and preparation method thereof | 佛山湘潭大学绿色智造研究院 | 2021-08-06 | — | — | CN | disclosed |
| EP-2922845-B1 | ANTHELMINTIC COMPOUNDS AND COMPOSITIONS AND METHOD OF USING THEREOF | MERIAL INC (US) | 2018-06-20 | — | — | EP | disclosed |