Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | FNTA | P49354 | 1/20 | 0.37 |
| ▸ | FNTB | P49356 | 1/20 | 0.37 |
| ▸ | XDH | P47989 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 8/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | F2 | P00734 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.32 |
| ▸ | FEN1 | P39748 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.31 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30971585 | 0.83 | DGAT1 (0.34) | PKM | |
| SCHEMBL15500615 | 0.80 | MAPT (0.33) | ALDH1A1POLBHTTSMN1; SMN2LMNA | |
| SCHEMBL15562123 | 0.78 | DGAT1 (0.36) | ALOX5APFEN1NPC1 | |
| SCHEMBL30797402 | 0.75 | NPC1 (0.34) | HTTNPC1 | |
| SCHEMBL14821056 | 0.75 | CSNK2A1 (0.40) | CSNK2A1 | |
| SCHEMBL12582909 | 0.74 | DGAT1 (0.30) | — | |
| SCHEMBL14824076 | 0.74 | BUB1 (0.32) | CSNK2A1 | |
| SCHEMBL2077800 | 0.74 | PKM (0.50) | PKMFNTAFNTBXDHKDM4E | |
| SCHEMBL30101425 | 0.73 | NPC1 (0.34) | KDM4EKMT2AMEN1ALDH1A1KDR | |
| SCHEMBL31038919 | 0.73 | DGAT1 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 57 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111303159-A | Pyrazole carboxamide compounds for the treatment of diseases mediated by Bruton's Tyrosine Kinase (BTK) | 豪夫迈·罗氏有限公司 | 2020-06-19 | — | — | CN | disclosed |
| US-20200181154-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2020-06-11 | — | — | US | disclosed |
| CN-106922146-B | Pyrazole carboxamide compounds for the treatment of diseases mediated by Bruton's Tyrosine Kinase (BTK) | 豪夫迈·罗氏有限公司 | 2020-05-26 | — | — | CN | disclosed |
| US-20190194209-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2019-06-27 | — | — | US | disclosed |
| EP-2758051-B1 | CYANOMETHYLPYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-11 | — | — | EP | disclosed |
| EP-2758051-B1 | CYANOMETHYLPYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2018-04-11 | — | — | EP | disclosed |
| US-20180057500-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2018-03-01 | — | — | US | disclosed |
| EP-3201186-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS FOR USE IN THE TREAMENT OF DISORDERS MEDIATED BY BRUTON'S TYROSINE KINASE (BTK) | F. Hoffmann-La Roche AG (CH) | 2017-08-09 | — | — | EP | disclosed |
| EP-2758377-B1 | CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-08-02 | — | — | EP | disclosed |
| EP-2758389-B1 | PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME (US) | 2017-06-07 | — | — | EP | disclosed |
| WO-2013040863-A1 | CYCLOALKYLNITRILE PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013041042-A1 | PYRAZOLE CARBOXAMIDES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-03-28 | — | — | WO | disclosed |
| WO-2013043964-A1 | ACYCLIC CYANOETHYLPYRAZOLES AS JANUS KINASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-03-28 | — | — | WO | disclosed |
| WO-2012156334-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | F. HOFFMANN-LA ROCHE AG (CH) | 2012-11-22 | — | — | WO | disclosed |
| US-20120295885-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | HOFFMANN-LA ROCHE INC. | 2012-11-22 | — | — | US | disclosed |
| US-20110130393-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110130393-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2011-06-02 | — | — | US | disclosed |
| US-20110130393-A1 | INHIBITORS OF JANUS KINASES | MERCK SHARP & DOHME LLC | 2011-06-02 | — | — | US | disclosed |
| WO-2010014453-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2010-02-04 | — | — | WO | disclosed |
| WO-2010014453-A1 | INHIBITORS OF JANUS KINASES | MERCK & CO., INC. (US) | 2010-02-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057500-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS AND METHODS OF USE | BTK, IRAK3, IRAK1 | PKM 422/4885FNTA 3314/4885FNTB 2973/4885 |
| US-20200181154-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS AND METHODS OF USE | BTK, IRAK3, IRAK1 | PKM 422/4885FNTA 3314/4885FNTB 2973/4885 |
| US-20110130393-A1 | INHIBITORS OF JANUS KINASES | JAK2, JAK3, JAK1 | PKM 2053/4885FNTA 3053/4885FNTB 3677/4885 |
| US-20190194209-A1 | PYRAZOLE CARBOXAMIDE COMPOUNDS AND METHODS OF USE | BTK, IRAK3, IRAK1 | PKM 422/4885FNTA 3314/4885FNTB 2973/4885 |
| US-20120295885-A1 | INHIBITORS OF BRUTON'S TYROSINE KINASE | BTK, SYK, LYN | PKM 2195/4885FNTA 4111/4885FNTB 4187/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.