Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 3/20 | 0.52 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.49 |
| ▸ | HPGDS | O60760 | 3/20 | 0.48 |
| ▸ | TTK | P33981 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 3/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.47 |
| ▸ | FLT3 | P36888 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.46 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.44 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.44 |
| ▸ | WNT1 | P04628 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | LIPC | P11150 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15431560 | 0.93 | GPR119 (0.55) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL16899750 | 0.92 | MET (0.51) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL16907836 | 0.92 | MET (0.51) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL15416610 | 0.92 | MET (0.53) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL15416687 | 0.91 | MET (0.51) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL15415993 | 0.90 | GPR119 (0.54) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL16899801 | 0.90 | MET (0.51) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL15416250 | 0.90 | MET (0.49) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL15431641 | 0.90 | GPR119 (0.52) | METIRAK1HPGDSTTKFGFR3 | |
| SCHEMBL15416081 | 0.89 | MET (0.54) | METIRAK1HPGDSTTKFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10314841-B2 | Substituted pyrazoles as IRAK inhibitors | MERCK PATENT GMBH (DE) | 2019-06-11 | — | — | US | disclosed |
| US-20180169094-A1 | PYRIMIDINE PYRAZOLYL DERIVATIVES AND THEIR USE AS IRAK INHIBITORS | MERCK PATENT GMBH (DE) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169094-A1 | PYRIMIDINE PYRAZOLYL DERIVATIVES AND THEIR USE AS IRAK INHIBITORS | IRAK2, IRAK3, IRAK1 | MET 2313/4885IRAK1 3/4885HPGDS 2282/4885 |
| US-10314841-B2 | Substituted pyrazoles as IRAK inhibitors | IRAK2, IRAK3, IRAK1 | MET 1617/4885IRAK1 3/4885HPGDS 3075/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.