Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 6/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 6/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 6/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.37 |
| ▸ | AKT1 | P31749 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL680932 | 0.86 | DRD2 (0.45) | DRD2SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL684402 | 0.81 | DRD2 (0.45) | DRD2SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL12219063 | 0.79 | DRD2 (0.49) | DRD2SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL681492 | 0.78 | DRD2 (0.45) | DRD2SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL681051 | 0.77 | DRD2 (0.51) | DRD2OPRM1HDAC4HSD11B1AKT1 | |
| SCHEMBL13012452 | 0.76 | DRD2 (0.49) | DRD2SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL17424825 | 0.76 | DRD2 (0.49) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL192358 | 0.75 | SLC6A2 (0.46) | DRD2SLC6A2SLC6A4SLC6A3OPRM1 | |
| SCHEMBL681284 | 0.75 | DRD2 (0.45) | DRD2SLC6A2SLC6A4SLC6A3HDAC4 | |
| SCHEMBL684441 | 0.75 | DRD2 (0.51) | DRD2OPRM1HDAC4HSD11B1AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180169099-A1 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | ARRAY BIOPHARMA INC. (US) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180169099-A1 | HYDROXYLATED AND METHOXYLATED PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS | AKT1, AKT2, AKT1S1 | DRD2 4186/4885SLC6A2 3153/4885SLC6A4 2692/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.