Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | OGA | O60502 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MLYCD | O95822 | 1/20 | 0.30 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7230926 | 0.80 | ALDH1A1 (0.57) | ALDH1A1KDM4ETDP1KCNJ1MAPT | |
| SCHEMBL12824358 | 0.79 | ALDH1A1 (0.44) | ALDH1A1KDM4ETDP1KCNJ1ALOX15 | |
| SCHEMBL1749460 | 0.75 | KDM4E (0.44) | ALDH1A1KDM4ECYP1A2SMN1; SMN2OGA | |
| SCHEMBL21358923 | 0.72 | OGA (0.43) | ALDH1A1KDM4ECYP1A2SMN1; SMN2OGA | |
| SCHEMBL3129610 | 0.72 | KDM4E (0.42) | ALDH1A1KDM4ECYP1A2SMN1; SMN2OGA | |
| SCHEMBL16742553 | 0.71 | ALDH1A1 (0.42) | ALDH1A1KDM4EOGATDP1KCNJ1 | |
| SCHEMBL21369613 | 0.71 | OGA (0.42) | ALDH1A1KDM4ECYP1A2SMN1; SMN2OGA | |
| SCHEMBL24862745 | 0.67 | OGA (0.57) | ALDH1A1KDM4ESMN1; SMN2OGATDP1 | |
| SCHEMBL4100380 | 0.67 | CSNK2A2 (0.46) | OGAMAPT | |
| SCHEMBL2411773 | 0.66 | ALDH1A1 (0.41) | ALDH1A1KDM4ETDP1KCNJ1MLYCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018109198-A1 | BICYCLIC OGA INHIBITOR COMPOUNDS | JANSSEN PHARMACEUTICA NV (BE) | 2018-06-21 | — | — | WO | disclosed |