Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | APAF1 | O14727 | 1/20 | 0.35 |
| ▸ | G6PD | P11413 | 1/20 | 0.35 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 5/20 | 0.31 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.30 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20284239 | 0.80 | ALDH1A1 (0.50) | ALDH1A1KDM4ETDP1KCNJ1MAPT | |
| SCHEMBL4838205 | 0.79 | ALDH1A1 (0.53) | ALDH1A1KDM4ETDP1KCNJ1MAPT | |
| SCHEMBL6630471 | 0.73 | ALDH1A1 (0.48) | ALDH1A1KDM4ETDP1KCNJ1MAPT | |
| SCHEMBL12824358 | 0.72 | ALDH1A1 (0.44) | ALDH1A1KDM4ETDP1KCNJ1ALOX15 | |
| SCHEMBL550353 | 0.71 | — | — | |
| SCHEMBL24166650 | 0.71 | ALDH1A1 (0.37) | ALDH1A1KDM4EMAPTALOX15HSD17B10 | |
| SCHEMBL16742553 | 0.71 | ALDH1A1 (0.42) | ALDH1A1KDM4ETDP1KCNJ1MAPT | |
| SCHEMBL15330581 | 0.70 | ALDH1A1 (0.58) | ALDH1A1KDM4ETDP1MAPTHSD17B10 | |
| SCHEMBL31482100 | 0.70 | ALDH1A1 (0.69) | ALDH1A1KDM4ETDP1MAPTALOX15 | |
| SCHEMBL3500305 | 0.70 | KDM4E (0.42) | ALDH1A1KDM4ETDP1MAPTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250368636-A1 | NOVEL HETEROCYCLIC COMPOUND, SALT THEREOF, AND LUMINESCENT SUBSTRATE COMPOSITION | THE UNIVERSITY OF ELECTRO-COMMUNICATIONS (JP) | 2025-12-04 | — | — | US | disclosed |
| CN-114163437-B | Substituted pyrazolo [1,5-a ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2025-03-04 | — | — | CN | disclosed |
| US-11998545-B2 | Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors | ARRAY BIOPHARMA INC. (US) | 2024-06-04 | — | — | US | disclosed |
| US-20240066029-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | ARRAY BIOPHARMA INC. | 2024-02-29 | — | — | US | disclosed |
| WO-2023238683-A1 | NOVEL HETEROCYCLIC COMPOUND AND SALT THEREOF, AND LUMINESCENT SUBSTRATE COMPOSITION | 国立大学法人電気通信大学 | 2023-12-14 | — | — | WO | disclosed |
| WO-2023238683-A1 | NOVEL HETEROCYCLIC COMPOUND AND SALT THEREOF, AND LUMINESCENT SUBSTRATE COMPOSITION | 国立大学法人電気通信大学 | 2023-12-14 | — | — | WO | disclosed |
| CN-117120435-A | ABHD6 antagonists | 小野药品工业株式会社 | 2023-11-24 | — | — | CN | disclosed |
| US-11807612-B2 | Heterocyclic compound and salt thereof, and luminescent substrate composition | THE UNIVERSITY OF ELECTRO-COMMUNICATIONS (JP) | 2023-11-07 | — | — | US | disclosed |
| US-11807612-B2 | Heterocyclic compound and salt thereof, and luminescent substrate composition | THE UNIVERSITY OF ELECTRO-COMMUNICATIONS (JP) | 2023-11-07 | — | — | US | disclosed |
| US-11807612-B2 | Heterocyclic compound and salt thereof, and luminescent substrate composition | THE UNIVERSITY OF ELECTRO-COMMUNICATIONS (JP) | 2023-11-07 | — | — | US | disclosed |
| WO-2015075025-A1 | TRICYCLIC IMIDAZOLE COMPOUNDS AS INHIBITORS OF TRYPTOPHAN HYDROXYLASE | ACTELION PHARMACEUTICALS LTD (CH) | 2015-05-28 | — | — | WO | disclosed |
| US-7910579-B2 | Benzoxazole derivatives | TOHOKU UNIVERSITY (JP) | 2011-03-22 | — | — | US | disclosed |
| US-20100021385-A1 | BENZOXAZOLE DERIVATIVES | TOHOKU UNIVERSITY (JP) | 2010-01-28 | — | — | US | disclosed |
| CN-101472902-A | Novel piperazine compounds and their use as HCV polymerase inhibitors | JAPAN TOBACCO INC (JP) | 2009-07-01 | — | — | CN | disclosed |
| CN-1257886-C | Dehydroamino acids compounds | HOFFMANN LA ROCHE (CH) | 2006-05-31 | — | — | CN | disclosed |
| CN-1398252-A | dehydroamino acid compounds | HOFFMANN LA ROCHE (CH) | 2003-02-19 | — | — | CN | disclosed |
| US-6515124-B2 | (Z)-2-((2-bromo-4-(((3-hydroxybenzyl)amino)carbonyl)benzoyl) -amino)pent-2-enoic acid, for example; useful for treating psoriasis | HOFFMAN-LA ROCHE INC. | 2003-02-04 | — | — | US | disclosed |
| EP-1261579-A1 | DEHYDROAMINO ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2002-12-04 | — | — | EP | disclosed |
| US-20020161237-A1 | Dehydroamino acids | HOFFMANN-LA ROCHE INC. | 2002-10-31 | — | — | US | disclosed |
| WO-2001058853-A1 | DEHYDROAMINO ACIDS | F. HOFFMANN-LA ROCHE AG (CH) | 2001-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020161237-A1 | Dehydroamino acids | HSD3B1, CYP8B1, TH | ALDH1A1 1300/4885KDM4E 2779/4885TDP1 2456/4885 |
| US-20100021385-A1 | BENZOXAZOLE DERIVATIVES | CBX7, KIT, BMX | ALDH1A1 1195/4885KDM4E 1190/4885TDP1 1704/4885 |
| US-11807612-B2 | Heterocyclic compound and salt thereof, and luminescent substrate composition | RXFP4, NR2E3, ARRB1 | ALDH1A1 2259/4885KDM4E 2139/4885TDP1 3442/4885 |
| US-11998545-B2 | Substituted pyrazolo[1,5-a]pyridine compounds as RET kinase inhibitors | RET, ROR1, BRAF | ALDH1A1 2868/4885KDM4E 889/4885TDP1 1003/4885 |
| US-20250368636-A1 | NOVEL HETEROCYCLIC COMPOUND, SALT THEREOF, AND LUMINESCENT SUBSTRATE COMPOSITION | OXSR1, RER1, NR2E3 | ALDH1A1 2261/4885KDM4E 3521/4885TDP1 4496/4885 |
| US-20240066029-A1 | SUBSTITUTED PYRAZOLO[1,5-A]PYRIDINE COMPOUNDS AS RET KINASE INHIBITORS | RET, ROR1, BRAF | ALDH1A1 2868/4885KDM4E 889/4885TDP1 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.