Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PSMB5 | P28074 | 13/20 | 0.81 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.81 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.81 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.81 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.81 |
| ▸ | PSMB11 | A5LHX3 | 1/20 | 0.81 |
| ▸ | PSMD11 | O00231 | 1/20 | 0.81 |
| ▸ | PSMD12 | O00232 | 1/20 | 0.81 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.81 |
| ▸ | PSMA7 | O14818 | 1/20 | 0.81 |
| ▸ | PSMD3 | O43242 | 1/20 | 0.81 |
| ▸ | CTSB | P07858 | 1/20 | 0.81 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.81 |
| ▸ | PSMC3 | P17980 | 1/20 | 0.81 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.81 |
| ▸ | CYP3A5 | P20815 | 1/20 | 0.81 |
| ▸ | CYP3A7 | P24462 | 1/20 | 0.81 |
| ▸ | PSMA1 | P25786 | 1/20 | 0.81 |
| ▸ | PSMA2 | P25787 | 1/20 | 0.81 |
| ▸ | PSMA3 | P25788 | 1/20 | 0.81 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21156771 | 1.00 | PSMB5 (0.81) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL8267376 | 1.00 | PSMB5 (0.81) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL21192145 | 1.00 | PSMB5 (0.81) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL8281922 | 1.00 | PSMB5 (0.81) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL18871666 | 1.00 | PSMB5 (0.81) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL8268435 | 1.00 | PSMB5 (0.81) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL20284323 | 0.97 | PSMB5 (0.76) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL23516840 | 0.96 | PSMB5 (0.77) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL12957389 | 0.95 | PSMB5 (0.73) | PSMB5PSMB9PSMB8PSMB10PSMB2 | |
| SCHEMBL17987914 | 0.92 | CTRL (0.70) | PSMB5PSMB9PSMB8PSMB10PSMB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210179663-A1 | COMPOUNDS FOR PROTEASOME ENZYME INHIBITION | PROTEOLIX, INC. | 2021-06-17 | — | — | US | disclosed |
| US-20200325172-A1 | Compounds for proteasome enzyme inhibition | PROTEOLIX, INC. | 2020-10-15 | — | — | US | disclosed |
| US-20200071356-A1 | COMPOUNDS FOR PROTEASOME | PROTEOLIX, INC. | 2020-03-05 | — | — | US | disclosed |
| US-20180170962-A1 | COMPOUNDS FOR PROTEASOME ENZYME INHIBITION | ONYX THERAPEUTICS INC (US) | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180170962-A1 | COMPOUNDS FOR PROTEASOME ENZYME INHIBITION | PSMB1, PSMB9, PSMB3 | PSMB5 14/4885PSMB9 2/4885PSMB8 27/4885 |
| US-20200071356-A1 | COMPOUNDS FOR PROTEASOME | PSMB1, PSMB9, PSMB2 | PSMB5 12/4885PSMB9 2/4885PSMB8 20/4885 |
| US-20200325172-A1 | Compounds for proteasome enzyme inhibition | PSMB1, PSMB9, PSMB3 | PSMB5 14/4885PSMB9 2/4885PSMB8 27/4885 |
| US-20210179663-A1 | COMPOUNDS FOR PROTEASOME ENZYME INHIBITION | PSMB1, PSMB9, PSMB3 | PSMB5 14/4885PSMB9 2/4885PSMB8 27/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.