Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NSD2 | O96028 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | MMP2 | P08253 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11074257 | 0.85 | ALDH1A1 (0.49) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL24512632 | 0.82 | HDAC3 (0.43) | MAPTMEN1KMT2AKDM4EMCL1 | |
| SCHEMBL27552130 | 0.79 | ALDH1A1 (0.42) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL12428822 | 0.77 | MAOB (0.44) | MAPTMEN1KMT2AALDH1A1LMNA | |
| SCHEMBL14458139 | 0.76 | MEN1 (0.48) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL3661233 | 0.75 | KDM4E (0.54) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL561095 | 0.74 | MAOB (0.62) | MAPTMEN1KMT2AALDH1A1MCL1 | |
| SCHEMBL7628578 | 0.73 | KEAP1 (0.41) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL1734943 | 0.73 | AKR1C3 (0.42) | MAPTMEN1KMT2AALDH1A1KDM4E | |
| SCHEMBL7485032 | 0.73 | CYP3A4 (0.50) | MAPTMEN1KMT2AALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3556435-B1 | CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE | BEIJING SHOWBY PHARMACEUTICAL CO LTD (CN) | 2020-10-28 | — | — | EP | disclosed |
| EP-3556435-A1 | CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE | Beijing Showby Pharmaceutical Co., Ltd. (CN) | 2019-10-23 | — | — | EP | disclosed |
| WO-2018108089-A1 | CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE | 北京硕佰医药科技有限责任公司 | 2018-06-21 | — | — | WO | disclosed |