Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 5/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | MMP2 | P08253 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | BLM | P54132 | 1/20 | 0.34 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12071026 | 0.97 | EPHX1 (0.44) | EPHX1DHODHTP53CA12CA1 | |
| SCHEMBL14611740 | 0.97 | EPHX1 (0.44) | EPHX1DHODHTP53CA12CA1 | |
| SCHEMBL8277386 | 0.97 | EPHX1 (0.44) | EPHX1DHODHTP53CA12CA1 | |
| SCHEMBL16838380 | 0.89 | — | — | |
| SCHEMBL4646100 | 0.80 | EPHX1 (0.38) | EPHX1DHODHTP53CA12CA1 | |
| SCHEMBL9289846 | 0.80 | CPN1 (0.44) | EPHX1LMNAPMP22 | |
| SCHEMBL13205863 | 0.80 | SHBG (0.43) | — | |
| SCHEMBL24355684 | 0.78 | DPP4 (0.35) | — | |
| SCHEMBL24355686 | 0.78 | DPP4 (0.35) | — | |
| SCHEMBL24355685 | 0.78 | DPP4 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11802105-B2 | Treprostinil derivatives and compositions and uses thereof | Corsair Pharma, Inc. (US) | 2023-10-31 | — | — | US | disclosed |
| US-10988435-B2 | Treprostinil derivatives and compositions and uses thereof | Corsair Pharma, Inc. (US) | 2021-04-27 | — | — | US | disclosed |
| US-20200347006-A1 | TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF | Corsair Pharma, Inc. (US) | 2020-11-05 | — | — | US | disclosed |
| US-10246403-B2 | Treprostinil derivatives and compositions and uses thereof | Corsair Pharma, Inc. (US) | 2019-04-02 | — | — | US | disclosed |
| US-20180170855-A1 | TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF | Corsair Pharma, Inc. | 2018-06-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10246403-B2 | Treprostinil derivatives and compositions and uses thereof | PTGIS, PTGIR, PDE3A | EPHX1 224/4885DHODH 589/4885TP53 2889/4885 |
| US-20200347006-A1 | TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF | PTGIS, PTGIR, PDE3A | EPHX1 224/4885DHODH 589/4885TP53 2889/4885 |
| US-10988435-B2 | Treprostinil derivatives and compositions and uses thereof | PTGIS, PTGIR, PDE3A | EPHX1 224/4885DHODH 589/4885TP53 2889/4885 |
| US-11802105-B2 | Treprostinil derivatives and compositions and uses thereof | PTGIS, PTGIR, PDE3A | EPHX1 224/4885DHODH 589/4885TP53 2889/4885 |
| US-20180170855-A1 | TREPROSTINIL DERIVATIVES AND COMPOSITIONS AND USES THEREOF | PTGIS, PTGIR, PDE3A | EPHX1 224/4885DHODH 589/4885TP53 2889/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.