Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCRL | Q16602 | 17/20 | 0.51 |
| ▸ | CALCA | P06881 | 3/20 | 0.48 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1393800 | 0.81 | CALCRL (0.55) | CALCRLCALCA | |
| SCHEMBL1395308 | 0.81 | CALCRL (0.55) | CALCRLCALCA | |
| SCHEMBL2021754 | 0.80 | CALCRL (0.53) | CALCRLCALCA | |
| SCHEMBL1394285 | 0.80 | CALCRL (0.62) | CALCRLCALCA | |
| SCHEMBL1395295 | 0.80 | CALCRL (0.56) | CALCRLCALCAMAP2K2 | |
| SCHEMBL1394349 | 0.78 | CALCRL (0.53) | CALCRLCALCA | |
| SCHEMBL379814 | 0.78 | CALCRL (0.53) | CALCRLCALCA | |
| SCHEMBL2029588 | 0.78 | CALCRL (0.63) | CALCRLCALCA | |
| SCHEMBL1394446 | 0.77 | CALCRL (0.62) | CALCRLCALCA | |
| SCHEMBL1394421 | 0.77 | CALCRL (0.62) | CALCRLCALCA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1951051-B1 | SPIROHYDANTOIN TRICYCLIC CGRP RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2012-10-03 | — | — | EP | disclosed |
| US-7968540-B2 | Spirohydantoin tricyclic CGRP receptor antagonists | MERCK SHARP & DOHME CORP. (US) | 2011-06-28 | — | — | US | disclosed |
| US-20090281080-A1 | Spirohydantoin Tricyclic CGRP Receptor Antagonists | MERCK SHARP & DOHME LLC | 2009-11-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281080-A1 | Spirohydantoin Tricyclic CGRP Receptor Antagonists | BDKRB1, BDKRB2, CCKBR | CALCRL 4/4885CALCA 19/4885MAP2K2 4657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.