Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 11/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 11/20 | 0.42 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | CASP7 | P55210 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20296611 | 0.90 | ADORA2A (0.40) | ADORA2AADORA1KDM4EPABPC1CASP1 | |
| SCHEMBL18344192 | 0.84 | ADORA2A (0.42) | ADORA2AADORA1CRHR1KDM4ESMN1; SMN2 | |
| SCHEMBL23965741 | 0.79 | RAB9A (0.46) | ADORA2AADORA1CYP1A2SMN1; SMN2 | |
| SCHEMBL20296398 | 0.78 | NPC1 (0.44) | KDM4EPABPC1CASP1CASP7HSD17B10 | |
| SCHEMBL20296754 | 0.78 | NPC1 (0.44) | KDM4EPABPC1CASP1CASP7HSD17B10 | |
| SCHEMBL20296152 | 0.78 | RAB9A (0.49) | ADORA2AADORA1CRHR1SYKADRA1A | |
| SCHEMBL21638128 | 0.78 | SMN1; SMN2 (0.47) | ADORA2AADORA1CRHR1CYP1A2SMN1; SMN2 | |
| SCHEMBL21638127 | 0.78 | SMN1; SMN2 (0.47) | ADORA2AADORA1CRHR1CYP1A2SMN1; SMN2 | |
| SCHEMBL29364773 | 0.77 | CHRM5 (0.46) | ADORA2AADORA1 | |
| SCHEMBL18344189 | 0.76 | SYK (0.40) | ADORA2AADORA1CRHR1SYKCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180179194-A1 | NADPH OXIDASE 4 INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179194-A1 | NADPH OXIDASE 4 INHIBITORS | NOX4, NOX1, CYBB | ADORA2A 3834/4885ADORA1 3540/4885CRHR1 3677/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.