Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 13/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | CRACR2A | Q9BSW2 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20298594 | 0.91 | P2RX7 (0.40) | P2RX7CRACR2ACNR2HCRTR1 | |
| SCHEMBL20298565 | 0.85 | AKT1 (0.38) | CRACR2A | |
| SCHEMBL20298567 | 0.84 | P2RX7 (0.38) | P2RX7 | |
| SCHEMBL20298551 | 0.82 | MC1R (0.37) | CRACR2ACNR2HCRTR1 | |
| SCHEMBL20315932 | 0.82 | MAPT (0.47) | P2RX7DPP4CNR2HCRTR1 | |
| SCHEMBL19767312 | 0.81 | HCRTR1 (0.41) | P2RX7DPP4CNR2HCRTR1GRM4 | |
| SCHEMBL24543387 | 0.79 | ACKR3 (0.42) | P2RX7CNR2HCRTR1 | |
| SCHEMBL16372435 | 0.79 | ACKR3 (0.42) | P2RX7CNR2HCRTR1 | |
| SCHEMBL19771728 | 0.79 | ACKR3 (0.42) | P2RX7CNR2HCRTR1 | |
| SCHEMBL21273811 | 0.79 | ACKR3 (0.42) | P2RX7CNR2HCRTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558956-B1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2020-10-28 | — | — | EP | claimed |
| US-20200087271-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2020-03-19 | — | — | US | claimed |
| EP-3558956-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | Syngenta Participations AG (CH) | 2019-10-30 | — | — | EP | claimed |
| WO-2018114657-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2018-06-28 | — | — | WO | claimed |
| EP-3558956-B1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2020-10-28 | — | — | EP | disclosed |
| EP-3558956-B1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2020-10-28 | — | — | EP | disclosed |
| US-20200087271-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2020-03-19 | — | — | US | disclosed |
| US-20200087271-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2020-03-19 | — | — | US | disclosed |
| EP-3558956-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | Syngenta Participations AG (CH) | 2019-10-30 | — | — | EP | disclosed |
| WO-2018114657-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018114657-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | SYNGENTA PARTICIPATIONS AG (CH) | 2018-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200087271-A1 | N-CYCLOBUTYL-THIAZOL-5-CARBOXAMIDES WITH NEMATICIDAL ACTIVITY | TUBA3C, NIT2, TUBB | P2RX7 1077/4885DPP4 441/4885CRACR2A 2592/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.