Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.54 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.54 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.54 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | CDC25A | P30304 | 1/20 | 0.51 |
| ▸ | CDC25B | P30305 | 1/20 | 0.51 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | APAF1 | O14727 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12334403 | 0.90 | LCK (0.47) | LCKSIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL22625286 | 0.89 | LCK (0.66) | LCKMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL677432 | 0.87 | MAPT (0.62) | LCKMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL10134130 | 0.83 | CSNK2A2 (0.49) | LCKSIRT2SIRT1SIRT3SIRT5 | |
| SCHEMBL25165798 | 0.82 | LCK (0.50) | LCKMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL1225662 | 0.81 | CYP19A1 (0.57) | SIRT2SIRT1SIRT3SIRT5MAPT | |
| SCHEMBL26172921 | 0.81 | APP (0.55) | LCKMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL25165754 | 0.80 | LCK (0.49) | LCKMAPTKMT2AMEN1L3MBTL1 | |
| SCHEMBL3372898 | 0.80 | LCK (0.56) | LCKSIRT1MAPTKMT2AMEN1 | |
| SCHEMBL22625287 | 0.80 | CSNK2A2 (0.59) | LCKMAPTKMT2AMEN1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018114965-A1 | CLPX INHIBITORY COMPOUNDS FOR THE TREATMENT OF MULTI RESISTANT STAPHYLOCOCCUS AUREUS VIRULENCE AND FOR THE TREATMENT OF LEUKEMIA | Technische Universität München (DE) | 2018-06-28 | — | — | WO | disclosed |