Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.56 |
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | ALPL | P05186 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | ELANE | P08246 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30381697 | 1.00 | LCK (0.56) | LCKMAOBMAOASIRT1MAPT | |
| SCHEMBL22625286 | 0.89 | LCK (0.66) | LCKMAPTKMT2AALPLALPI | |
| SCHEMBL677432 | 0.83 | MAPT (0.62) | LCKMAOBMAOAMAPTKMT2A | |
| SCHEMBL4135006 | 0.81 | CYP19A1 (0.57) | MAOBMAOASIRT1KMT2AALPL | |
| SCHEMBL245217 | 0.81 | LCK (0.57) | LCKMAOBMAOAMAPTKMT2A | |
| SCHEMBL30381597 | 0.80 | PARP1 (0.62) | LCKMAPTKMT2AALPLALPI | |
| SCHEMBL22625287 | 0.80 | CSNK2A2 (0.59) | LCKMAPTKMT2AALPLALPI | |
| SCHEMBL20299553 | 0.80 | LCK (0.66) | LCKMAPTKMT2AALPLALPI | |
| SCHEMBL7147011 | 0.80 | PARP1 (0.62) | LCKMAPTKMT2AALPLALPI | |
| SCHEMBL20299501 | 0.80 | LCK (0.56) | LCKSIRT1MAPTKMT2AALPL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110028407-B | Method for preparing spiro [ cyclopropane-1, 2 ' -indene ] -1 ', 3 ' -diketone compound | 苏州大学 | 2021-08-27 | — | — | CN | disclosed |
| CN-111233884-B | Method for synthesizing gamma-butyrolactone containing spiro 1, 3-indandione structure by using microchannel reaction device | 南京工业大学 | 2021-01-26 | — | — | CN | disclosed |
| CN-111233884-A | Method for synthesizing gamma-butyrolactone containing spiro 1, 3-indandione structure by using microchannel reaction device | 南京工业大学 | 2020-06-05 | — | — | CN | disclosed |
| CN-110028407-A | A kind of method preparing -1 ', 3 '-dione compounds of spiral shell [cyclopropane -1,2 '-indenes] | 苏州大学 | 2019-07-19 | — | — | CN | disclosed |
| EP-1474690-B1 | E2 DISPLACEMENT ASSAY FOR IDENTIFYING INHIBITORS OF HPV | BOEHRINGER INGELHEIM CA LTD (CA) | 2010-10-13 | — | — | EP | disclosed |
| EP-1474690-B1 | E2 DISPLACEMENT ASSAY FOR IDENTIFYING INHIBITORS OF HPV | BOEHRINGER INGELHEIM CA LTD (CA) | 2010-10-13 | — | — | EP | disclosed |
| US-6825176-B2 | SYNTHESIS AND USE OF A PROBE THAT BINDS WITH SPECIFICITY TO THE TRANSACTIVATION DOMAIN (TAD) OF HUMAN PAPILLOMAVIRUS (HPV) E2 TO FORM A COMPLEX, WHICH IS CAPABLE OF BEING DISPLACED BY INHIBITORS OF HPV | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2004-11-30 | — | — | US | disclosed |
| US-20030194698-A1 | E2 displacement assay for identifying inhibitors of HPV | BOEHRINGER INGELHEIM (CANADA) LTD. (CA) | 2003-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030194698-A1 | E2 displacement assay for identifying inhibitors of HPV | WRN, TP53, NUTF2 | LCK 2626/4885MAOB 4065/4885MAOA 4213/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.