SCHEMBL677432

SCHEMBL677432

O=C1C(=Cc2ccccc2)C(=O)c2ccccc21

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 5/20 0.62
KMT2A Q03164 5/20 0.62
MEN1 O00255 3/20 0.62
HPGD P15428 3/20 0.62
L3MBTL1 Q9Y468 2/20 0.62
CDC25A P30304 1/20 0.62
CDC25B P30305 1/20 0.62
CTDSP1 Q9GZU7 1/20 0.62
TDP1 Q9NUW8 1/20 0.62
LCK P06239 2/20 0.58
USP2 O75604 1/20 0.56
PKM P14618 1/20 0.56
ALDH1A1 P00352 3/20 0.53
CRHBP P24387 1/20 0.53
CRHR2 Q13324 1/20 0.53
HTT P42858 3/20 0.52
POLB P06746 1/20 0.52
TUBB4A P04350 1/20 0.52
TUBB P07437 1/20 0.52
TUBA3C P0DPH7 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22625286 0.93 LCK (0.66) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL29491367 0.91 HPGD (0.54) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL4726286 0.88 TUBB4A (0.65) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL7898058 0.87 CYP1A2 (0.56) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL20299501 0.87 LCK (0.56) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL4740488 0.86 MEN1 (0.60) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL30175403 0.86 MEN1 (0.60) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL4740487 0.86 MEN1 (0.60) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL8778476 0.86 TUBB4A (0.52) MAPTKMT2AMEN1HPGDL3MBTL1
SCHEMBL8778480 0.86 TUBB4A (0.52) MAPTKMT2AMEN1HPGDL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-120136788-A Method for synthesizing pyrazole spiro derivative by copper catalysis 江苏师范大学 2025-06-13 CN claimed
CN-114957119-B Tetrahydroquinoline spiro 1, 3-indene diketone derivative and preparation method and application thereof 武汉大学中南医院 2023-06-16 CN claimed
CN-112724042-B Synthesis method of one-pot polysubstituted decalin derivative 甘肃农业大学 2023-04-28 CN claimed
CN-114957119-A Tetrahydroquinaxospiro 1, 3-indandione derivative and preparation method and application thereof 武汉大学中南医院 2022-08-30 CN claimed
CN-111233884-A Method for synthesizing gamma-butyrolactone containing spiro 1, 3-indandione structure by using microchannel reaction device 南京工业大学 2020-06-05 CN claimed
EP-0319296-A2 Photopolymerisable composition Horsell Plc (GB) 1989-06-07 EP claimed
JP-2000869-A None JP disclosed
WO-2026098527-A1 COMPOUND AND USE THEREOF IN PREPARATION OF ANTI-INFLAMMATORY DRUG 中国人民解放军陆军军医大学 2026-05-15 WO disclosed
CN-120136788-A Method for synthesizing pyrazole spiro derivative by copper catalysis 江苏师范大学 2025-06-13 CN disclosed
CN-120136788-A Method for synthesizing pyrazole spiro derivative by copper catalysis 江苏师范大学 2025-06-13 CN disclosed
CN-112209907-B Method for synthesizing dihydrofuran containing 1, 3-indenodione spiro framework by utilizing microchannel reaction device 南京先进生物材料与过程装备研究院有限公司 2025-03-18 CN disclosed
CN-116162076-B Spirocyclic gamma-butyrolactone containing carboxylic acid tert-butyl ester and 1, 3-indene diketone structure and preparation method thereof 南京工业大学 2024-03-29 CN disclosed
CN-114957119-B Tetrahydroquinoline spiro 1, 3-indene diketone derivative and preparation method and application thereof 武汉大学中南医院 2023-06-16 CN disclosed
WO-2000017206-A1 TETRACYCLIC HETEROCYCLES AS ANTIMICROBIAL AGENTS CUBIST PHARMACEUTICALS, INC. (US) 2000-03-30 WO disclosed
JP-H02869-A PHOTOPOLYMERIZABLE COMPOSITION, PHOTOSENSITIVE PRINTING PLATE AND ITS PRODUCTION COOKSON GROUP PLC 1990-01-05 JP disclosed
EP-0319296-A3 PHOTOPOLYMERISABLE COMPOSITION Horsell Plc (GB) 1989-10-11 EP disclosed
EP-0319296-A2 Photopolymerisable composition Horsell Plc (GB) 1989-06-07 EP disclosed
EP-0319296-A2 Photopolymerisable composition Horsell Plc (GB) 1989-06-07 EP disclosed
US-4326064-A CORONARODILATING ACTIVITY VIGANTE BRIGITA A 1982-04-20 US disclosed
US-4252956-A CORONARY ARTERY DILATORS VIGANTE BRIGITA A 1981-02-24 US disclosed