Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 1.00 |
| ▸ | NPC1 | O15118 | 2/20 | 1.00 |
| ▸ | MAPT | P10636 | 2/20 | 1.00 |
| ▸ | HPGD | P15428 | 2/20 | 1.00 |
| ▸ | HTT | P42858 | 2/20 | 1.00 |
| ▸ | RAB9A | P51151 | 2/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 1.00 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
| ▸ | XBP1 | P17861 | 1/20 | 1.00 |
| ▸ | CYP2C19 | P33261 | 1/20 | 1.00 |
| ▸ | LMNA | P02545 | 4/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.71 |
| ▸ | POLB | P06746 | 2/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.71 |
| ▸ | TP53 | P04637 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20302771 | 0.88 | KDM4E (0.78) | KDM4ENPC1MAPTHPGDHTT | |
| SCHEMBL20302758 | 0.86 | MAPT (0.75) | KDM4ENPC1MAPTHPGDHTT | |
| SCHEMBL20302756 | 0.84 | KDM4E (0.72) | KDM4ENPC1MAPTHPGDHTT | |
| SCHEMBL20302801 | 0.84 | KDM4E (0.72) | KDM4ENPC1MAPTHPGDHTT | |
| SCHEMBL15540128 | 0.83 | MAPT (1.00) | KDM4ENPC1MAPTHPGDHTT | |
| SCHEMBL29675943 | 0.83 | MAPT (1.00) | KDM4ENPC1MAPTHPGDHTT | |
| SCHEMBL20302789 | 0.82 | KDM4E (0.69) | KDM4ENPC1MAPTHPGDHTT | |
| Tegavivint SCHEMBL14947676 | 0.81 | NPSR1 (0.68) | KDM4ENPC1MAPTHPGDHTT | |
| SCHEMBL13366831 | 0.81 | NPSR1 (0.68) | KDM4ENPC1MAPTHPGDHTT | |
| Tegavivint SCHEMBL31694538 | 0.81 | NPSR1 (0.68) | KDM4ENPC1MAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
| US-10947188-B2 | Small molecule ferroptosis inducers | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2021-03-16 | — | — | US | disclosed |
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-10-17 | — | — | US | disclosed |
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 2019-10-17 | — | — | US | disclosed |
| WO-2018118711-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2018-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10947188-B2 | Small molecule ferroptosis inducers | GPX4, AIFM2, GPX1 | KDM4E 2315/4885NPC1 365/4885MAPT 4344/4885 |
| US-20190315681-A1 | SMALL MOLECULE FERROPTOSIS INDUCERS | GPX4, AIFM2, GPX1 | KDM4E 2315/4885NPC1 365/4885MAPT 4344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.