Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 12/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 12/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 12/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.47 |
| ▸ | TSHR | P16473 | 9/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 8/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 5/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | USP2 | O75604 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.45 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20302512 | 0.87 | MAPT (0.50) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL20303063 | 0.87 | KDM4C (0.56) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL20302799 | 0.87 | MAPT (0.52) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL20302815 | 0.86 | KDM4C (0.50) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL20302513 | 0.76 | APLNR (0.48) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL26601183 | 0.72 | MAPT (0.57) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL30670683 | 0.72 | MAPT (0.57) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL31235833 | 0.72 | KDM4C (0.48) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL2683023 | 0.71 | KDM4C (0.49) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR | |
| SCHEMBL873390 | 0.70 | DHFR (0.55) | CYP1A2CYP3A4CYP2C19ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558307-B1 | 6,6-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME LLC (US) | 2023-05-03 | — | — | EP | disclosed |
| US-10836775-B2 | 6,6-fused heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor | MERCK SHARP & DOHME CORP. (US) | 2020-11-17 | — | — | US | disclosed |
| EP-3558307-A1 | 6,6-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | Merck Sharp & Dohme Corp. (US) | 2019-10-30 | — | — | EP | disclosed |
| US-20190315762-A1 | 6,6-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2019-10-17 | — | — | US | disclosed |
| WO-2018118735-A1 | 6,6-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190315762-A1 | 6,6-FUSED HETEROARYL PIPERIDINE ETHER ALLOSTERIC MODULATORS OF THE M4 MUSCARINIC ACETYLCHOLINE RECEPTOR | CHRM4, CHRM5, CHRM2 | CYP1A2 647/4885CYP3A4 342/4885CYP2C19 1438/4885 |
| US-10836775-B2 | 6,6-fused heteroaryl piperidine ether allosteric modulators of the M4 muscarinic acetylcholine receptor | CHRM4, CHRM5, CHRM2 | CYP1A2 647/4885CYP3A4 342/4885CYP2C19 1438/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.