SCHEMBL2030486

SCHEMBL2030486

O=Cc1cccc(-c2cccs2)n1

nearest known ligand 0.66

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 10/20 0.66
ALDH1A1 P00352 7/20 0.66
HPGD P15428 4/20 0.66
MAPT P10636 4/20 0.66
TDP1 Q9NUW8 3/20 0.66
L3MBTL1 Q9Y468 3/20 0.66
MEN1 O00255 3/20 0.66
KMT2A Q03164 3/20 0.66
NPC1 O15118 6/20 0.46
RAB9A P51151 5/20 0.46
HSD17B10 Q99714 4/20 0.46
CYP1A2 P05177 1/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44
CYP2C9 P11712 1/20 0.44
CYP2C19 P33261 1/20 0.44
CASP3 P42574 1/20 0.44
SENP8 Q96LD8 1/20 0.44
SENP7 Q9BQF6 1/20 0.44
SENP6 Q9GZR1 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30514101 1.00 KDM4E (0.66) KDM4EALDH1A1HPGDMAPTTDP1
SCHEMBL498897 0.80 KDM4E (1.00) KDM4EALDH1A1HPGDMAPTTDP1
SCHEMBL29476108 0.78 CCR1 (0.48) KDM4EALDH1A1TDP1L3MBTL1MEN1
SCHEMBL2151538 0.78 CCR1 (0.48) KDM4EALDH1A1TDP1L3MBTL1MEN1
SCHEMBL2162823 0.75 MAPT (0.46) KDM4EALDH1A1HPGDMAPTTDP1
SCHEMBL4534663 0.72 RAB9A (0.49) ALDH1A1RAB9ACYP1A2
SCHEMBL154819 0.72 KDM4E (0.73) KDM4EALDH1A1HPGDMAPTTDP1
SCHEMBL11563521 0.72 KDM4E (0.73) KDM4EALDH1A1HPGDMAPTTDP1
SCHEMBL1573541 0.72 KDM4E (0.73) KDM4EALDH1A1HPGDMAPTTDP1
SCHEMBL14538334 0.72 KDM4E (0.73) KDM4EALDH1A1HPGDMAPTTDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 37 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116404255-B Electrolyte additive for lithium ion battery and preparation method and application thereof 湖北万润新能源科技股份有限公司 2023-11-24 CN claimed
CN-116404255-A Electrolyte additive for lithium ion battery and preparation method and application thereof 湖北万润新能源科技股份有限公司 2023-07-07 CN claimed
CN-102089037-A Equilibrium dynamic mixtures containing stabilized hemiacetals for controlled release of active alcohols FIRMENICH & CIE 2011-06-08 CN claimed
EP-3129102-B1 IODONIUM ANALOGS AS INHIBITORS OF NADPH OXIDASES AND OTHER FLAVIN DEHYDROGENASES; FORMULATIONS THEREOF; AND USES THEREOF US HEALTH (US) 2025-06-18 EP disclosed
CN-116404255-B Electrolyte additive for lithium ion battery and preparation method and application thereof 湖北万润新能源科技股份有限公司 2023-11-24 CN disclosed
CN-116404255-A Electrolyte additive for lithium ion battery and preparation method and application thereof 湖北万润新能源科技股份有限公司 2023-07-07 CN disclosed
US-10738047-B2 Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH (US) 2020-08-11 US disclosed
US-10336743-B2 Aminopyrimidine kinase inhibitors Jasco Pharmaceuticals, LLC (US) 2019-07-02 US disclosed
US-20190048001-A1 IODONIUM ANALOGS AS INHIBITORS OF NADPH OXIDASES AND OTHER FLAVIN DEHYDROGENASES; FORMULATIONS THEREOF; AND USES THEREOF THE US SECRETARY DEPARTMENT OF HEALTH (US) 2019-02-14 US disclosed
US-10131659-B2 Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) 2018-11-20 US disclosed
US-20170247367-A1 AMINOPYRIMIDINE KINASE INHIBITORS P2K DYNAMICS INC. 2017-08-31 US disclosed
WO-2013066684-A1 AMINOPYRIMIDINE KINASE INHIBITORS Jasco Pharmaceuticals, LLC (US) 2013-05-10 WO disclosed
WO-2012145617-A2 AMINOPYRIMIDINE KINASE INHIBITORS Jasco Pharmaceuticals, LLC (US) 2012-10-26 WO disclosed
US-20120270892-A1 Aminopyrimidine Kinase Inhibitors Jasco Pharmaceuticals, LLC (US) 2012-10-25 US disclosed
US-20110152235-A1 Aminopyrimidine Kinase Inhibitors Jasco Pharmaceuticals, LLC (US) 2011-06-23 US disclosed
CN-102089037-A Equilibrium dynamic mixtures containing stabilized hemiacetals for controlled release of active alcohols FIRMENICH & CIE 2011-06-08 CN disclosed
EP-0946546-B1 PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE PF MEDICAMENT (FR) 2003-06-25 EP disclosed
US-6020345-A Pyridin-2-yl-methylamine derivatives, method of preparing and application as medicine PIERRE FABRE MEDICAMENT (FR) 2000-02-01 US disclosed
EP-0946546-A1 PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE PIERRE FABRE MEDICAMENT (FR) 1999-10-06 EP disclosed
WO-1998022459-A1 PYRIDIN-2-YL-METHYLAMINE DERIVATIVES, METHOD OF PREPARING AND APPLICATION AS MEDICINE PIERRE FABRE MEDICAMENT (FR) 1998-05-28 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20170247367-A1 AMINOPYRIMIDINE KINASE INHIBITORS PIM1, PIM2, PIM3 KDM4E 1116/4885ALDH1A1 3087/4885HPGD 3594/4885
US-20190048001-A1 IODONIUM ANALOGS AS INHIBITORS OF NADPH OXIDASES AND OTHER FLAVIN DEHYDROGENASES; FORMULATIONS THEREOF; AND USES THEREOF NOX5, CYBB, NOX1 KDM4E 3086/4885ALDH1A1 108/4885HPGD 56/4885
US-10131659-B2 Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof NOX5, CYBB, NOX1 KDM4E 3086/4885ALDH1A1 108/4885HPGD 56/4885
US-20120270892-A1 Aminopyrimidine Kinase Inhibitors PIM1, PIM2, PIM3 KDM4E 1380/4885ALDH1A1 3305/4885HPGD 3303/4885
US-10738047-B2 Iodonium analogs as inhibitors of NADPH oxidases and other flavin dehydrogenases; formulations thereof; and uses thereof NOX5, CYBB, NOX1 KDM4E 3086/4885ALDH1A1 108/4885HPGD 56/4885
US-20110152235-A1 Aminopyrimidine Kinase Inhibitors PIM1, PIM2, PIM3 KDM4E 1225/4885ALDH1A1 3532/4885HPGD 3330/4885
US-10336743-B2 Aminopyrimidine kinase inhibitors PIM1, PIM2, PIM3 KDM4E 1150/4885ALDH1A1 2942/4885HPGD 3472/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.