Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA3 | P07451 | 2/20 | 0.42 |
| ▸ | CA4 | P22748 | 2/20 | 0.42 |
| ▸ | CA6 | P23280 | 2/20 | 0.42 |
| ▸ | CA5A | P35218 | 2/20 | 0.42 |
| ▸ | CA7 | P43166 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CA13 | Q8N1Q1 | 2/20 | 0.42 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.42 |
| ▸ | CA5B | Q9Y2D0 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2030815 | 1.00 | LCK (0.50) | LCKPTGS2CYP3A4KDM4ELMNA | |
| SCHEMBL7645028 | 0.96 | LCK (0.44) | LCKPTGS2CYP3A4CA12CA1 | |
| SCHEMBL10296725 | 0.94 | LCK (0.48) | LCKPTGS2CYP3A4ALOX5CBS | |
| SCHEMBL11296041 | 0.92 | PTGS2 (0.48) | LCKPTGS2CYP3A4ALOX5CBS | |
| SCHEMBL16535327 | 0.92 | PTGS2 (0.48) | LCKPTGS2CYP3A4ALOX5CBS | |
| SCHEMBL2464261 | 0.92 | PTGS2 (0.48) | LCKPTGS2CYP3A4ALOX5CBS | |
| SCHEMBL2370035 | 0.92 | PTGS2 (0.48) | LCKPTGS2CYP3A4ALOX5CBS | |
| SCHEMBL17938807 | 0.92 | PTGS2 (0.48) | LCKPTGS2CYP3A4ALOX5CBS | |
| SCHEMBL17938809 | 0.92 | PTGS2 (0.48) | LCKPTGS2CYP3A4ALOX5CBS | |
| SCHEMBL17938768 | 0.92 | PTGS2 (0.48) | LCKPTGS2CYP3A4ALOX5CBS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8258322-B2 | Synthesis of hexahydrodibenzopyranones | WATSON LABORATORIES, INC. (US) | 2012-09-04 | — | — | US | disclosed |
| EP-2331519-A1 | IMPROVED SYNTHESIS OF HEXAHYDRODIBENZOPYRANONES | Watson Laboratories, Inc. (US) | 2011-06-15 | — | — | EP | disclosed |
| US-20100056811-A1 | Synthesis of Hexahydrodibenzopyranones | WATSON LABORATORIES, INC. | 2010-03-04 | — | — | US | disclosed |
| WO-2010022520-A1 | IMPROVED SYNTHESIS OF HEXAHYDRODIBENZOPYRANONES | DALTON CHEMICAL LABORATORIES INC. (CA) | 2010-03-04 | — | — | WO | disclosed |
| EP-0004753-B1 | PREPARATION OF TETRAHYDROBENZOXOCINS AND CIS-HEXAHYDRODIBENZOPYRANONES | ELI LILLY AND COMPANY (US) | 1982-05-26 | — | — | EP | disclosed |
| EP-0004753-A1 | Preparation of tetrahydrobenzoxocins and cis-hexahydrodibenzopyranones | ELI LILLY AND COMPANY (US) | 1979-10-17 | — | — | EP | disclosed |
| US-4171315-A | Preparation of cis-hexahydrodibenzopyranones | ELI LILLY AND COMPANY (US) | 1979-10-16 | — | — | US | disclosed |
| US-4148809-A | Process for preparing dl-cis-1-hydroxy-3-substituted-6,6-dimethyl-6,6a,7,8,10,10a-hexahydro-9H-dibenzo[b,d]pyran-9-ones | ELI LILLY AND COMPANY (US) | 1979-04-10 | — | — | US | disclosed |
| US-4131614-A | Process for preparing cis-hexahydrodibenzopyranones | ELI LILLY AND COMPANY (US) | 1978-12-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100056811-A1 | Synthesis of Hexahydrodibenzopyranones | GNE, GALE, UGDH | LCK 3375/4885PTGS2 1512/4885CYP3A4 86/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.