Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 3/20 | 0.46 |
| ▸ | GRIN3B | O60391 | 3/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.46 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.46 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.46 |
| ▸ | GRIN3A | Q8TCU5 | 3/20 | 0.46 |
| ▸ | FLT3 | P36888 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.42 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15826116 | 0.86 | KCNH2 (0.49) | KCNH2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8871896 | 0.83 | KCNH2 (0.50) | KCNH2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20309858 | 0.83 | KCNH2 (0.47) | KCNH2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL8873534 | 0.81 | KCNH2 (0.46) | KCNH2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL18152712 | 0.77 | GRIN2D (0.38) | KCNH2GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL18152714 | 0.76 | ALDH1A1 (0.40) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL15022789 | 0.76 | NQO2 (0.48) | HTT | |
| SCHEMBL17279192 | 0.76 | KCNH2 (0.62) | KCNH2FLT3PIM1PIM3PIM2 | |
| SCHEMBL13544181 | 0.75 | GRIN2D (0.51) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL18152810 | 0.75 | MDM2 (0.42) | KCNH2GRIN2DGRIN3BGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935244-B1 | NOVEL BENZIMIDAZOLE DERIVATIVES AS KINASE INHIBITORS | SELVITA S A (PL) | 2018-06-27 | — | — | EP | disclosed |