Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | ALKBH3 | Q96Q83 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.36 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.36 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.36 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.36 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.36 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.36 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18152622 | 0.88 | MGMT (0.39) | POLBMAPTCYP1A2GRIN2DGRIN3B | |
| SCHEMBL18152714 | 0.79 | ALDH1A1 (0.40) | SMN1; SMN2POLBMAPTCYP1A2CYP2C9 | |
| SCHEMBL28195339 | 0.77 | SMN1; SMN2 (0.46) | MDM2SMN1; SMN2PTGS1PTGS2POLB | |
| SCHEMBL18152723 | 0.76 | HTT (0.35) | MDM2SMN1; SMN2PTGS1PTGS2MAPT | |
| SCHEMBL18152712 | 0.75 | GRIN2D (0.38) | POLBMAPTGRIN2DGRIN3BGRIN1 | |
| SCHEMBL20309801 | 0.75 | KCNH2 (0.51) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL18152696 | 0.68 | RIPK1 (0.37) | SMN1; SMN2POLBMAPTCYP1A2CYP2C9 | |
| SCHEMBL2004140 | 0.68 | GRIN2D (0.40) | MDM2SMN1; SMN2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL28195340 | 0.67 | SMN1; SMN2 (0.45) | MDM2SMN1; SMN2PTGS1PTGS2POLB | |
| SCHEMBL28854614 | 0.65 | MEN1 (0.39) | MDM2SMN1; SMN2MAPTALDH1A1MGMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3283077-A2 | BROMODOMAIN INHIBITOR | Celgene Quanticel Research, Inc. (US) | 2018-02-21 | — | — | EP | disclosed |
| WO-2016168682-A2 | BROMODOMAIN INHIBITOR | CELGENE QUANTICEL RESEARCH, INC. (US) | 2016-10-20 | — | — | WO | disclosed |