Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | RECQL | P46063 | 1/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11499021 | 0.85 | KMT2A (0.50) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL2755842 | 0.84 | ALDH1A1 (0.77) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL10720580 | 0.83 | ALDH1A1 (0.51) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL8493065 | 0.81 | ALDH1A1 (0.59) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL8140708 | 0.81 | KDM4E (0.57) | ALDH1A1MAPTGAAKMT2ALMNA | |
| SCHEMBL30543830 | 0.80 | ALDH1A1 (0.58) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL312939 | 0.77 | HPGD (0.56) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL312938 | 0.77 | HPGD (0.56) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL30615127 | 0.77 | HPGD (0.56) | ALDH1A1MAPTGAAHTTKMT2A | |
| SCHEMBL1440034 | 0.77 | ALDH1A1 (0.53) | ALDH1A1MAPTGAAHTTHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3013798-B1 | FUSED TRICYCLIC UREA COMPOUNDS AS RAF KINASE AND/OR RAF KINASE DIMER INHIBITORS | BEIGENE LTD (KY) | 2018-06-27 | — | — | EP | disclosed |