Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 5/20 | 0.54 |
| ▸ | ESR2 | Q92731 | 5/20 | 0.54 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.49 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | MME | P08473 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10809828 | 0.87 | ESR1 (0.50) | ESR1ESR2SLC6A2 | |
| SCHEMBL5966674 | 0.86 | ESR1 (0.54) | ESR1ESR2SLC7A5HDAC1HDAC2 | |
| SCHEMBL4692054 | 0.84 | ESR1 (0.53) | ESR1ESR2SLC7A5TAAR1SLC6A2 | |
| SCHEMBL14520756 | 0.84 | HDAC3 (0.59) | SLC7A5HDAC3HDAC4HDAC1HDAC2 | |
| SCHEMBL12493560 | 0.83 | CHRM1 (0.53) | ESR1ESR2SLC7A5HDAC1HDAC2 | |
| SCHEMBL6715740 | 0.81 | EPHX2 (0.50) | ESR1ESR2SLC7A5CA1CA2 | |
| SCHEMBL11631386 | 0.79 | PTGS2 (0.61) | ESR1 | |
| SCHEMBL984527 | 0.79 | ESR1 (0.63) | ESR1ESR2SLC7A5TAAR1SLC6A2 | |
| SCHEMBL28334190 | 0.77 | ESR1 (0.49) | ESR1ESR2SLC7A5TAAR1SLC6A2 | |
| SCHEMBL28766017 | 0.77 | ESR1 (0.57) | ESR1ESR2SLC7A5TAAR1SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119224-A1 | TETRAHYDRO IMIDAZO[4,5-C]PYRIDINE DERIVATIVES AS PD-L1 INTERNALIZATION INDUCERS | INCYTE CORPORATION (US) | 2018-06-28 | — | — | WO | disclosed |