Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CPA3 | P15088 | 3/20 | 0.51 |
| ▸ | CPA1 | P15085 | 2/20 | 0.50 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.50 |
| ▸ | CPB1 | P15086 | 1/20 | 0.50 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.50 |
| ▸ | ALPI | P09923 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | XIAP | P98170 | 1/20 | 0.48 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.48 |
| ▸ | LTA4H | P09960 | 2/20 | 0.46 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948787 | 0.89 | FOLH1 (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL8728655 | 0.89 | FOLH1 (0.54) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL2945682 | 0.88 | MMP2 (0.55) | FOLH1 | |
| SCHEMBL6657008 | 0.87 | CYP1A2 (0.70) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL5710051 | 0.87 | CYP1A2 (0.59) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL4550704 | 0.87 | CYP1A2 (0.70) | HDAC3HDAC4HDAC1HDAC2HDAC8 | |
| SCHEMBL5017227 | 0.86 | MMP2 (0.57) | FOLH1 | |
| SCHEMBL28211408 | 0.86 | MMP2 (0.57) | FOLH1 | |
| SCHEMBL497369 | 0.86 | CYP1A2 (0.68) | CYP1A2CPA3CPA1FOLH1CPB1 | |
| SCHEMBL21895912 | 0.85 | CYP1A2 (0.67) | CYP1A2CPA3CPA1FOLH1CPB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150150819-A1 | COMPOSITIONS CONTAINING OPIOID ANTAGONISTS | MERCK SHARP & DOHME CORP. | 2015-06-04 | — | — | US | disclosed |
| US-20150126554-A1 | METHODS OF PREVENTING AND TREATING GASTROINTESTINAL DYSFUNCTION | ADOLOR CORPORATION | 2015-05-07 | — | — | US | disclosed |
| US-8946262-B2 | Methods of preventing and treating gastrointestinal dysfunction | ADOLOR CORPORATION (US) | 2015-02-03 | — | — | US | disclosed |
| US-20070092576-A1 | Micronizing with sugar excipient; stability and bioavailability; e.g. alvimopam; solid dosage forms | ADOLOR CORPORATION (US) | 2007-04-26 | — | — | US | disclosed |
| US-20070082053-A1 | Solid dispersions of opioid antagonists | ADOLOR CORPORATION (US) | 2007-04-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070082053-A1 | Solid dispersions of opioid antagonists | OPRK1, OPRD1, OPRM1 | HDAC3 502/4885HDAC4 1792/4885HDAC1 933/4885 |
| US-20150126554-A1 | METHODS OF PREVENTING AND TREATING GASTROINTESTINAL DYSFUNCTION | VIP, FABP2, SI | HDAC3 894/4885HDAC4 400/4885HDAC1 853/4885 |
| US-20070092576-A1 | Micronizing with sugar excipient; stability and bioavailability; e.g. alvimopam; solid dosage forms | OPRM1, OPRK1, OGFR | HDAC3 1523/4885HDAC4 2403/4885HDAC1 1696/4885 |
| US-20150150819-A1 | COMPOSITIONS CONTAINING OPIOID ANTAGONISTS | OPRK1, OPRM1, OPRD1 | HDAC3 1291/4885HDAC4 3521/4885HDAC1 2191/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.