Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 4/20 | 0.39 |
| ▸ | CA1 | P00915 | 4/20 | 0.39 |
| ▸ | CA9 | Q16790 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.36 |
| ▸ | MMP1 | P03956 | 1/20 | 0.36 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP8 | P22894 | 1/20 | 0.36 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.34 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.34 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3073635 | 0.81 | GRIN2D (0.40) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL6831380 | 0.78 | ALDH1A1 (0.44) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL13955312 | 0.77 | CA12 (0.41) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL15086931 | 0.76 | — | — | |
| SCHEMBL28417961 | 0.76 | CA12 (0.41) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL28415126 | 0.76 | CA12 (0.41) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL10591900 | 0.76 | CA1 (0.40) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL2955338 | 0.75 | CA12 (0.39) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL15723556 | 0.74 | EPHX1 (0.39) | CA12CA1CA9ALDH1A1ALDH2 | |
| SCHEMBL1793798 | 0.74 | EPHX1 (0.39) | CA12CA1CA9ALDH1A1ALDH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180177749-A1 | USE OF CYP EXPRESSION TO DIRECT THERAPEUTIC INTERVENTION IN CANCER | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180177749-A1 | USE OF CYP EXPRESSION TO DIRECT THERAPEUTIC INTERVENTION IN CANCER | EPHX1, EPHX2, CYP4X1 | CA12 1712/4885CA1 2369/4885CA9 834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.