Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | HPGD | P15428 | 4/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.38 |
| ▸ | MEN1 | O00255 | 4/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | RGS17 | Q9UGC6 | 2/20 | 0.38 |
| ▸ | RGS12 | O14924 | 2/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20317303 | 0.87 | ALDH1A1 (0.44) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20317307 | 0.87 | TDP1 (0.41) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20317234 | 0.86 | CDK2 (0.41) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20317345 | 0.85 | PDE5A (0.36) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20317347 | 0.84 | KMT2A (0.41) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20317280 | 0.84 | MAOA (0.47) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20346668 | 0.83 | TDP1 (0.40) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20317305 | 0.82 | CYP1A2 (0.46) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20317349 | 0.82 | AR (0.35) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 | |
| SCHEMBL20317340 | 0.82 | MAOA (0.51) | KDM4EALDH1A1MAPTHPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180179174-A1 | 12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME | THESAN PHARMACEUTICALS, INC. (US) | 2018-06-28 | — | — | US | disclosed |
| US-20180179174-A1 | 12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME | THESAN PHARMACEUTICALS, INC. (US) | 2018-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180179174-A1 | 12H-BENZO[b]XANTHEN-12-ONES, COMPOSITIONS CONTAINING, AND USES OF, SAME | AHR, NR1H2, NR1H3 | KDM4E 2074/4885ALDH1A1 1200/4885MAPT 2891/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.