Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.41 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.41 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.41 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.41 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.40 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.40 |
| ▸ | KDM6B | O15054 | 2/20 | 0.40 |
| ▸ | KDM5C | P41229 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | FABP7 | O15540 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | SLC13A3 | Q8WWT9 | 1/20 | 0.33 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9592005 | 1.00 | HTT (0.46) | HTTLMNAEGLN1ALKBH5SUCNR1 | |
| SCHEMBL2032263 | 0.94 | HTT (0.42) | HTTLMNAEGLN1ALKBH5SUCNR1 | |
| SCHEMBL4951808 | 0.91 | HTT (0.54) | HTTLMNAALDH1A1POLBFABP7 | |
| SCHEMBL28068757 | 0.87 | TSHR (0.48) | HTTLMNAALDH1A1TSHRGAA | |
| SCHEMBL9449439 | 0.87 | LMNA (0.46) | HTTLMNAALDH1A1TSHRMEN1 | |
| SCHEMBL30089474 | 0.83 | LMNA (0.39) | HTTLMNAEGLN1ALKBH5SUCNR1 | |
| SCHEMBL16125337 | 0.82 | LMNA (0.33) | HTTLMNAEGLN1ALKBH5SUCNR1 | |
| SCHEMBL509013 | 0.81 | HTT (0.50) | HTTLMNAALDH1A1TSHRMAPT | |
| SCHEMBL11912289 | 0.81 | LMNA (0.45) | LMNAEGLN1ALKBH5SUCNR1PHF8 | |
| SCHEMBL1405339 | 0.81 | LMNA (0.45) | LMNAEGLN1ALKBH5SUCNR1PHF8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011068403-A2 | NOVEL N-{3-ETHYNYLPHENYLAMINO)-6,7-BIS(2-METHOXYETHOXY)-4-QUINAZOLINAMJNE SALTS | ULTIMORPHIX TECHNOLOGIES B.V. (NL) | 2011-06-09 | — | — | WO | claimed |