Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26744659 | 0.92 | HRH2 (0.36) | CYP2D6CYP2C19SMN1; SMN2SIGMAR1TP53 | |
| SCHEMBL29323634 | 0.89 | HRH1 (0.36) | CYP2D6CYP2C19MAPK1RAB9AMEN1 | |
| SCHEMBL22296937 | 0.87 | KDM1A (0.42) | KDM1ACYP2D6CYP2C19SMN1; SMN2SIGMAR1 | |
| SCHEMBL20322411 | 0.86 | KDM4E (0.39) | KDM1ACYP2D6CYP2C19SMN1; SMN2SIGMAR1 | |
| SCHEMBL11572427 | 0.85 | — | — | |
| SCHEMBL14451172 | 0.85 | CYP2D6 (0.41) | CYP2D6CYP2C19ALDH1A1HTTHRH1 | |
| SCHEMBL4893159 | 0.85 | CYP2D6 (0.41) | CYP2D6CYP2C19ALDH1A1HTTHRH1 | |
| SCHEMBL25608425 | 0.83 | KDM1A (0.38) | KDM1ACYP2D6CYP2C19SIGMAR1CYP1A2 | |
| SCHEMBL13171585 | 0.83 | KDM1A (0.38) | KDM1ASIGMAR1MAPK1RAB9AMEN1 | |
| SCHEMBL29316649 | 0.83 | SIGMAR1 (0.40) | KDM1ACYP2D6CYP2C19SMN1; SMN2SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2018119448-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF RAPIDLY ACCELERATED FIBROSARCOMA POLYPEPTIDES | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |