Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11572427 | 1.00 | — | — | |
| SCHEMBL14451172 | 1.00 | CYP2D6 (0.41) | CYP2D6CYP2C19KDM4EHTTALDH1A1 | |
| SCHEMBL4894190 | 0.93 | MAPK1 (0.42) | CYP2D6CYP2C19KDM4EHTTALDH1A1 | |
| SCHEMBL735201 | 0.93 | ALDH1A1 (0.46) | CYP2D6CYP2C19KDM4EALDH1A1NPC1 | |
| SCHEMBL10961176 | 0.93 | CYP2D6 (0.41) | CYP2D6CYP2C19KDM4EALDH1A1HRH1 | |
| SCHEMBL13891364 | 0.93 | DRD2 (0.39) | CYP2D6CYP2C19KDM4EHTTHRH1 | |
| SCHEMBL13612608 | 0.91 | HRH1 (0.46) | CYP2D6CYP2C19KDM4EHTTALDH1A1 | |
| SCHEMBL22060473 | 0.91 | CYP2D6 (0.37) | CYP2D6CYP2C19KDM4EHTTALDH1A1 | |
| SCHEMBL29322718 | 0.90 | MAPK1 (0.40) | CYP2D6CYP2C19KDM4EALDH1A1 | |
| SCHEMBL11569854 | 0.90 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2018119357-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |
| EP-1867667-B1 | Method for manufacturing stabilized polyacetal resin | POLYPLASTICS CO (JP) | 2012-10-31 | — | — | EP | disclosed |
| US-20080271381-A1 | Method for manufacturing stabilized polyacetal resin, stabilized polyacetal resin, stabilized polyacetal resin composition, and molded article of stabilized polyacetal resin | POLYPLASTICS CO., LTD (JP) | 2008-11-06 | — | — | US | disclosed |
| EP-1867667-A1 | Method for manufacturing stabilized polyacetal resin, stabilized polyacetal resin, stabilized polyacetal resin composition, and molded article of stabilized polyacetal resin | Polyplastics Co., Ltd. (JP) | 2007-12-19 | — | — | EP | disclosed |