Known targets — ChEMBL curated mechanism
CACNA1CCACNA1DCACNA1FCACNA1SDPP4HTR1BHTR1D
The experimentally established mechanism targets of Benzoic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.47 |
| ▸ | SERPINE1 | P05121 | 2/20 | 0.44 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4958932 | 0.83 | TRPM8 (0.50) | TRPM8KCNA5ALDH1A1LMNATRPV1 | |
| SCHEMBL203238 | 0.80 | TRPM8 (0.49) | TRPM8KCNA5ALDH1A1LMNATRPV1 | |
| Ethylene Glycol SCHEMBL203237 | 0.80 | TRPM8 (0.46) | TRPM8SERPINE1KCNA5ALDH1A1LMNA | |
| Menthol SCHEMBL28946770 | 0.80 | TRPM8 (0.62) | TRPM8SERPINE1KCNA5ALDH1A1LMNA | |
| SCHEMBL9292733 | 0.77 | TRPM8 (0.47) | TRPM8KCNA5ALDH1A1LMNATRPV1 | |
| SCHEMBL9292729 | 0.77 | TRPM8 (0.47) | TRPM8SERPINE1KCNA5ALDH1A1LMNA | |
| SCHEMBL29449500 | 0.76 | TRPM8 (0.49) | TRPM8SERPINE1KCNA5ALDH1A1LMNA | |
| SCHEMBL8858055 | 0.75 | TRPM8 (0.48) | TRPM8SERPINE1KCNA5ALDH1A1LMNA | |
| SCHEMBL28404985 | 0.74 | TRPM8 (0.45) | TRPM8SERPINE1KCNA5ALDH1A1LMNA | |
| SCHEMBL3033238 | 0.73 | TRPM8 (0.51) | TRPM8KCNA5ALDH1A1LMNATRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8088872-B2 | Procatalyst composition including silyl ester internal donor and method | DOW GLOBAL TECHNOLOGIES LLC (US) | 2012-01-03 | — | — | US | disclosed |
| EP-2350144-A1 | PROCATALYST COMPOSITION INCLUDING SILYL ESTER INTERNAL DONOR AND METHOD | Dow Global Technologies LLC (US) | 2011-08-03 | — | — | EP | disclosed |
| WO-2010065361-A1 | PROCATALYST COMPOSITION INCLUDING SILYL ESTER INTERNAL DONOR AND METHOD | DOW GLOBAL TECHNOLOGIES INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20100130709-A1 | Procatalyst Composition Including Silyl Ester Internal Donor and Method | W. R. GRACE & CO.-CONN. | 2010-05-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100130709-A1 | Procatalyst Composition Including Silyl Ester Internal Donor and Method | GNE, NANS, ELANE | TRPM8 4579/4885SERPINE1 2765/4885KCNA5 3902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.