Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | PKM | P14618 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | SLC9A1 | P19634 | 2/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5616784 | 0.88 | KCNMA1 (0.54) | KCNMA1ALDH1A1KMT2ANPSR1MEN1 | |
| SCHEMBL9616134 | 0.84 | KCNMA1 (0.55) | KCNMA1ALDH1A1KMT2ANPSR1MEN1 | |
| SCHEMBL25862494 | 0.81 | KCNMA1 (0.64) | KCNMA1ALDH1A1GAAKMT2ANPSR1 | |
| SCHEMBL8849556 | 0.78 | KCNMA1 (0.47) | KCNMA1ALDH1A1GAAKMT2ANPSR1 | |
| SCHEMBL25078456 | 0.77 | KCNMA1 (0.58) | KCNMA1ALDH1A1GAAKMT2ANPSR1 | |
| SCHEMBL8844809 | 0.75 | KCNMA1 (0.55) | KCNMA1ALDH1A1GAAKMT2ANPSR1 | |
| SCHEMBL23349069 | 0.72 | KCNMA1 (0.53) | KCNMA1ALDH1A1GAAKMT2ANPSR1 | |
| SCHEMBL4209963 | 0.72 | KCNMA1 (0.64) | KCNMA1ALDH1A1GAAKMT2AMAPT | |
| SCHEMBL18599169 | 0.72 | KCNMA1 (0.55) | KCNMA1NPSR1TSHRSMN1; SMN2RAB9A | |
| SCHEMBL24599961 | 0.71 | KCNMA1 (0.51) | KCNMA1ALDH1A1GAAKMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119286-A1 | BICYCLIC HETEROAROMATIC COMPOUNDS AS IMMUNOMODULATORS | INCYTE CORPORATION (US) | 2018-06-28 | — | — | WO | disclosed |