Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 1/20 | 0.31 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21637014 | 0.90 | DNPH1 (0.38) | — | |
| SCHEMBL20324789 | 0.88 | STING1 (0.31) | STING1 | |
| SCHEMBL20325339 | 0.88 | POLB (0.31) | STING1 | |
| SCHEMBL15289753 | 0.83 | CYP2A6 (0.37) | STING1 | |
| SCHEMBL26195756 | 0.83 | CYP2A6 (0.37) | STING1 | |
| SCHEMBL18520482 | 0.83 | CYP2A6 (0.37) | STING1 | |
| SCHEMBL24160862 | 0.78 | HRH4 (0.49) | — | |
| SCHEMBL20327226 | 0.75 | STING1 (0.35) | STING1 | |
| SCHEMBL22355531 | 0.73 | POLRMT (0.43) | — | |
| SCHEMBL24340458 | 0.73 | POLRMT (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |