Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPRT1 | P00492 | 10/20 | 0.49 |
| ▸ | PNP | P00491 | 6/20 | 0.48 |
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20324648 | 0.90 | HPRT1 (0.48) | HPRT1PNPNT5EPOLBTGM2 | |
| SCHEMBL26196873 | 0.84 | ADORA3 (0.48) | HPRT1PNPNT5EPOLB | |
| SCHEMBL18519687 | 0.84 | HPRT1 (0.45) | HPRT1PNPNT5EPOLB | |
| SCHEMBL9124912 | 0.83 | ADORA3 (0.52) | HPRT1PNP | |
| SCHEMBL9124915 | 0.83 | ADORA3 (0.52) | HPRT1PNP | |
| SCHEMBL20324729 | 0.83 | HPRT1 (0.44) | HPRT1PNPNT5EPOLB | |
| SCHEMBL20325253 | 0.83 | NT5E (0.48) | HPRT1PNPNT5EPOLBTGM2 | |
| SCHEMBL22524007 | 0.82 | PNP (0.43) | HPRT1PNPNT5EPOLB | |
| SCHEMBL20324698 | 0.82 | HPRT1 (0.43) | HPRT1PNPNT5EPOLB | |
| SCHEMBL20324630 | 0.81 | STING1 (0.46) | NT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |