Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HPRT1 | P00492 | 7/20 | 0.47 |
| ▸ | PNP | P00491 | 4/20 | 0.47 |
| ▸ | TGM2 | P21980 | 1/20 | 0.45 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.43 |
| ▸ | STING1 | Q86WV6 | 1/20 | 0.42 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.42 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.42 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22381969 | 0.84 | ADORA3 (0.52) | HPRT1PNPADORA3STING1 | |
| SCHEMBL21942766 | 0.84 | ADORA3 (0.52) | HPRT1PNPADORA3STING1 | |
| SCHEMBL20324550 | 0.84 | POLB (0.48) | NT5EPOLBSTING1P2RY2P2RY4 | |
| SCHEMBL20324662 | 0.83 | POLB (0.56) | NT5EPOLBHPRT1PNPTGM2 | |
| SCHEMBL20324562 | 0.83 | HPRT1 (0.49) | NT5EPOLBHPRT1PNPTGM2 | |
| SCHEMBL22524061 | 0.82 | PNP (0.52) | NT5EPOLBHPRT1PNPTGM2 | |
| SCHEMBL20326898 | 0.81 | STING1 (0.42) | NT5EPOLBTGM2FUT5STING1 | |
| SCHEMBL20325346 | 0.80 | POLB (0.64) | NT5EPOLBHPRT1TGM2FUT5 | |
| SCHEMBL20325348 | 0.80 | POLB (0.64) | NT5EPOLBHPRT1TGM2FUT5 | |
| SCHEMBL20326983 | 0.80 | STING1 (0.40) | POLBSTING1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |