Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STING1 | Q86WV6 | 7/20 | 0.47 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.42 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.41 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.41 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 3/20 | 0.40 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.39 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.39 |
| ▸ | TGM2 | P21980 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20324836 | 1.00 | STING1 (0.47) | STING1F2FUT5P2RY2P2RY4 | |
| SCHEMBL22524118 | 0.94 | STING1 (0.48) | STING1F2FUT5P2RY2P2RY4 | |
| SCHEMBL20324898 | 0.93 | STING1 (0.48) | STING1F2FUT5P2RY2P2RY4 | |
| SCHEMBL20327551 | 0.93 | STING1 (0.48) | STING1F2FUT5P2RY2P2RY4 | |
| SCHEMBL20327546 | 0.93 | STING1 (0.48) | STING1F2FUT5P2RY2P2RY4 | |
| SCHEMBL20327210 | 0.93 | STING1 (0.48) | STING1F2FUT5P2RY2P2RY4 | |
| SCHEMBL20327545 | 0.92 | FUT5 (0.45) | STING1F2FUT5NT5EPOLB | |
| SCHEMBL21943938 | 0.85 | FUT5 (0.53) | STING1F2FUT5P2RY2P2RY4 | |
| SCHEMBL20327045 | 0.85 | POLB (0.48) | STING1F2FUT5P2RY2P2RY4 | |
| SCHEMBL20324708 | 0.85 | POLB (0.48) | STING1F2FUT5P2RY2P2RY4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |