Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | STING1 | Q86WV6 | 4/20 | 0.45 |
| ▸ | TERT | O14746 | 1/20 | 0.44 |
| ▸ | FUT5 | Q11128 | 1/20 | 0.43 |
| ▸ | P2RY2 | P41231 | 1/20 | 0.43 |
| ▸ | P2RY4 | P51582 | 1/20 | 0.43 |
| ▸ | P2RY6 | Q15077 | 1/20 | 0.43 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.41 |
| ▸ | TGM2 | P21980 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20324900 | 0.97 | POLB (0.49) | POLBSTING1TERTFUT5P2RY2 | |
| SCHEMBL20326982 | 0.97 | POLB (0.49) | POLBSTING1TERTFUT5P2RY2 | |
| SCHEMBL20327217 | 0.93 | POLB (0.47) | POLBSTING1TERTFUT5P2RY2 | |
| SCHEMBL20326933 | 0.92 | POLB (0.52) | POLBSTING1TERTP2RY2P2RY4 | |
| SCHEMBL20324791 | 0.89 | POLB (0.47) | POLBSTING1TERTFUT5P2RY2 | |
| SCHEMBL21540039 | 0.86 | POLB (0.49) | POLBSTING1TERTF2 | |
| SCHEMBL21133201 | 0.85 | POLB (0.47) | POLBSTING1TERTFUT5P2RY2 | |
| SCHEMBL20325289 | 0.85 | POLB (0.45) | POLBSTING1TERTP2RY1 | |
| SCHEMBL20325348 | 0.85 | POLB (0.64) | POLBFUT5P2RY2P2RY4P2RY6 | |
| SCHEMBL20325346 | 0.85 | POLB (0.64) | POLBFUT5P2RY2P2RY4P2RY6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118665-A1 | CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |