Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | STING1 | Q86WV6 | 16/20 | 0.47 |
| ▸ | NT5E | P21589 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23477263 | 0.93 | NT5E (0.48) | STING1NT5E | |
| SCHEMBL20326953 | 0.91 | STING1 (0.49) | POLBSTING1NT5E | |
| SCHEMBL20325358 | 0.91 | STING1 (0.49) | POLBSTING1NT5E | |
| SCHEMBL22080410 | 0.88 | NT5E (0.51) | STING1NT5E | |
| SCHEMBL22930650 | 0.86 | POLB (0.51) | POLBSTING1 | |
| SCHEMBL20326933 | 0.84 | POLB (0.52) | POLBSTING1 | |
| SCHEMBL20325346 | 0.83 | POLB (0.64) | POLBNT5E | |
| SCHEMBL20325348 | 0.83 | POLB (0.64) | POLBNT5E | |
| SCHEMBL21132776 | 0.82 | NT5E (0.54) | POLBNT5E | |
| SCHEMBL22930658 | 0.82 | POLB (0.53) | POLBNT5E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018118664-A1 | COMBINATIONS OF PD-1 ANTAGONISTS AND CYCLIC DINUCLEOTIDE STING AGONISTS FOR CANCER TREATMENT | MERCK SHARP & DOHME CORP. (US) | 2018-06-28 | — | — | WO | disclosed |