Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 1/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.30 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.30 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.30 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | CDK2 | P24941 | 1/20 | 0.30 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20332232 | 0.92 | PDE10A (0.37) | TTKPDE10APDE3BPDE3A | |
| SCHEMBL21252083 | 0.88 | PDE10A (0.34) | TTKPDE10APIK3CAMAP4K1MAP3K12 | |
| SCHEMBL21240401 | 0.88 | PDCD1 (0.34) | TTKPDE10APIK3CAMAP4K1PDE3B | |
| SCHEMBL20331743 | 0.85 | FGFR4 (0.33) | TTKPDE10APDE3BPDE3ACHRM3 | |
| SCHEMBL21252126 | 0.82 | LRRK2 (0.41) | TTKPDE10AMAP3K12 | |
| SCHEMBL20331732 | 0.82 | ABL1 (0.32) | TTKABL1MAP4K1MAP3K12 | |
| SCHEMBL21240363 | 0.81 | PDE10A (0.39) | PDE10APDE3BPDE3A | |
| SCHEMBL20331865 | 0.81 | PDE10A (0.37) | PDE10AMAP3K12PDE3BPDE3A | |
| SCHEMBL21252104 | 0.81 | ABL1 (0.36) | TTKPDE10AABL1MAP4K1MAP3K12 | |
| SCHEMBL20330834 | 0.80 | TTK (0.37) | TTKMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |