Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.37 |
| ▸ | PDE3B | Q13370 | 9/20 | 0.37 |
| ▸ | PDE3A | Q14432 | 9/20 | 0.37 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.37 |
| ▸ | NTSR1 | P30989 | 3/20 | 0.35 |
| ▸ | NEK2 | P51955 | 4/20 | 0.35 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21252174 | 0.94 | PIK3CA (0.37) | NTSR1NEK2 | |
| SCHEMBL21252083 | 0.92 | PDE10A (0.34) | PDE10AMAP3K12 | |
| SCHEMBL20332232 | 0.89 | PDE10A (0.37) | PDE10APDE3BPDE3ANTSR1ACACB | |
| SCHEMBL21240363 | 0.89 | PDE10A (0.39) | PDE10APDE3BPDE3ANTSR1ACACB | |
| SCHEMBL24488230 | 0.89 | PDE10A (0.39) | PDE10APDE3BPDE3AMAP3K12NTSR1 | |
| SCHEMBL20332035 | 0.85 | PDE10A (0.37) | PDE10APDE3BPDE3AMAP3K12NTSR1 | |
| SCHEMBL21252280 | 0.85 | TTK (0.38) | PDE10APDE3BPDE3AMAP3K12NEK2 | |
| SCHEMBL21252027 | 0.84 | PDE10A (0.40) | PDE10APDE3BPDE3ANTSR1 | |
| SCHEMBL21252087 | 0.83 | MAP4K4 (0.39) | PDE10APDE3BPDE3AMAP3K12 | |
| SCHEMBL21252468 | 0.83 | LRRK2 (0.42) | PDE10AMAP3K12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-B1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | ABBISKO THERAPEUTICS CO LTD (CN) | 2022-06-08 | — | — | EP | disclosed |
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |