Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | MAP3K12 | Q12852 | 3/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.30 |
| ▸ | CSF1R | P07333 | 1/20 | 0.30 |
| ▸ | KIT | P10721 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20332234 | 0.92 | PDE9A (0.36) | ABL1PDE9AMAP4K1TTK | |
| SCHEMBL21240064 | 0.89 | PDE9A (0.32) | MAP3K12PDE9AMAP4K1 | |
| SCHEMBL21252476 | 0.89 | MAP3K12 (0.34) | MAP3K12MAP4K1 | |
| SCHEMBL21252104 | 0.86 | ABL1 (0.36) | ABL1MAP3K12PDE9AMAP4K1TTK | |
| SCHEMBL20331736 | 0.82 | TTK (0.34) | ABL1MAP3K12MAP4K1TTK | |
| SCHEMBL21240252 | 0.81 | PDE9A (0.37) | PDE9AMAP4K1TTK | |
| SCHEMBL21252283 | 0.81 | MAP3K12 (0.32) | MAP3K12MAP4K1 | |
| SCHEMBL21251781 | 0.80 | JAK2 (0.36) | MAP3K12TTK | |
| SCHEMBL21252119 | 0.80 | PDE9A (0.36) | PDE9ATTKCSF1R | |
| SCHEMBL20332232 | 0.79 | PDE10A (0.37) | TTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3524603-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | Abbisko Therapeutics Co., Ltd. (CN) | 2019-08-14 | — | — | EP | disclosed |
| WO-2018113584-A1 | FGFR4 INHIBITOR, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USE THEREOF | 上海和誉生物医药科技有限公司 | 2018-06-28 | — | — | WO | disclosed |