Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.45 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 4/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28346940 | 1.00 | HDAC1 (0.54) | HDAC1HDAC6L3MBTL1LMNAALDH1A1 | |
| SCHEMBL31403464 | 0.88 | GPR119 (0.46) | HDAC1HDAC6SETD7GPR119MEN1 | |
| SCHEMBL30774994 | 0.88 | GPR119 (0.47) | HDAC1HDAC6SETD7GPR119MEN1 | |
| SCHEMBL17086710 | 0.87 | HDAC1 (0.53) | HDAC1HDAC6L3MBTL1LMNAALDH1A1 | |
| SCHEMBL20684921 | 0.87 | ALDH1A1 (0.47) | HDAC1HDAC6L3MBTL1ALDH1A1SETD7 | |
| SCHEMBL18083710 | 0.87 | ALDH1A1 (0.47) | HDAC1HDAC6L3MBTL1ALDH1A1SETD7 | |
| SCHEMBL18083774 | 0.87 | ALDH1A1 (0.47) | HDAC1HDAC6L3MBTL1ALDH1A1SETD7 | |
| SCHEMBL15055262 | 0.87 | GPR119 (0.50) | GPR119MAPTKDM4E | |
| SCHEMBL14198702 | 0.87 | GPR119 (0.50) | GPR119MAPTKDM4E | |
| SCHEMBL12340707 | 0.87 | GPR119 (0.50) | GPR119MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110573497-A | Histone deacetylase inhibitors | 生物马林药物股份有限公司 | 2019-12-13 | — | — | CN | disclosed |
| WO-2018119362-A2 | HISTONE DEACETYLASE INHIBITORS | BIOMARIN PHARMACEUTICALS INC. (US) | 2018-06-28 | — | — | WO | disclosed |