Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | THRB | P10828 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.50 |
| ▸ | APEX1 | P27695 | 1/20 | 0.50 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD4 | P21917 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2278775 | 0.89 | GAA (0.49) | GAATHRBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL10074441 | 0.84 | HDAC1 (0.62) | GAATHRBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20333157 | 0.83 | MEN1 (0.60) | GAASMN1; SMN2ALDH1A1KDM4EMEN1 | |
| SCHEMBL20333556 | 0.81 | CHRM2 (0.56) | ALDH1A1MEN1USP2KMT2AHIF1A | |
| SCHEMBL20828408 | 0.81 | HDAC1 (0.62) | GAATHRBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL2787677 | 0.81 | HDAC1 (0.67) | ALDH1A1KDM4EHIF1AL3MBTL1CYP2D6 | |
| SCHEMBL22628928 | 0.81 | CYP2D6 (0.50) | GAATHRBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20333557 | 0.81 | CYP2D6 (0.45) | GAATHRBSMN1; SMN2ALDH1A1KDM4E | |
| SCHEMBL20333553 | 0.80 | CHRM2 (0.51) | GAATHRBSMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL3013154 | 0.80 | ALDH1A1 (0.61) | GAATHRBSMN1; SMN2ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018119362-A2 | HISTONE DEACETYLASE INHIBITORS | BIOMARIN PHARMACEUTICALS INC. (US) | 2018-06-28 | — | — | WO | disclosed |