Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 7/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MMP3 | P08254 | 3/20 | 0.51 |
| ▸ | HRH2 | P25021 | 4/20 | 0.50 |
| ▸ | HRH1 | P35367 | 4/20 | 0.50 |
| ▸ | MMP2 | P08253 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.46 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP13 | P45452 | 1/20 | 0.46 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20332712 | 1.00 | HRH3 (0.60) | HRH3HDAC1HDAC2MAPTALDH1A1 | |
| SCHEMBL20332716 | 0.94 | HRH3 (0.54) | HRH3HDAC1HDAC2MAPTALDH1A1 | |
| SCHEMBL12408526 | 0.94 | HRH3 (0.66) | HRH3HDAC1HDAC2MAPTALDH1A1 | |
| SCHEMBL5526919 | 0.94 | HRH3 (0.66) | HRH3HDAC1HDAC2MAPTALDH1A1 | |
| SCHEMBL7387284 | 0.94 | HRH3 (0.66) | HRH3HDAC1HDAC2MAPTALDH1A1 | |
| SCHEMBL7983991 | 0.94 | HRH3 (0.66) | HRH3HDAC1HDAC2MAPTALDH1A1 | |
| SCHEMBL5519875 | 0.91 | HRH3 (0.62) | HRH3HDAC1HDAC2MAPTALDH1A1 | |
| SCHEMBL29444063 | 0.88 | HDAC1 (0.67) | HRH3HDAC1HDAC2ALDH1A1MMP3 | |
| SCHEMBL18079151 | 0.88 | HDAC1 (0.67) | HRH3HDAC1HDAC2ALDH1A1MMP3 | |
| SCHEMBL16841044 | 0.88 | HDAC1 (0.67) | HRH3HDAC1HDAC2ALDH1A1MMP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2018112649-A1 | AMIDINE SUBSTITUTED ANALOGUES AND USES THEREOF | VERLYX PHARMA INC. (CA) | 2018-06-28 | — | — | WO | disclosed |