Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TLR2 | O60603 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13681687 | 0.87 | DEGS1 (0.49) | ALDH1A1DEGS1LMNAKMT2ATSHR | |
| SCHEMBL13681690 | 0.85 | DEGS1 (0.48) | ALDH1A1DEGS1EPHX2LMNAKMT2A | |
| SCHEMBL13681686 | 0.85 | ALDH1A1 (0.44) | ALDH1A1DEGS1LMNAKMT2ATSHR | |
| SCHEMBL20326400 | 0.82 | ALDH1A1 (0.40) | ALDH1A1DEGS1EPHX2LMNAKMT2A | |
| SCHEMBL277842 | 0.81 | LMNA (0.43) | EPHX2LMNATSHRGAASMN1; SMN2 | |
| SCHEMBL20230893 | 0.80 | TLR2 (0.44) | ALDH1A1EPHX2LMNAKMT2ATSHR | |
| SCHEMBL22787027 | 0.80 | LMNA (0.50) | ALDH1A1LMNAKMT2ATSHRGAA | |
| SCHEMBL19977983 | 0.79 | EPHX1 (0.50) | LMNAKMT2ATSHRTLR2CYP3A4 | |
| SCHEMBL19977980 | 0.79 | TSHR (0.46) | ALDH1A1EPHX2LMNAKMT2ATSHR | |
| SCHEMBL11814798 | 0.79 | ALDH1A1 (0.40) | ALDH1A1DEGS1EPHX2LMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3689868-A1 | TETRAHYDRONAPHTHALENE AND TETRAHYDROISOQUINOLINE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS | Arvinas Operations, Inc. (US) | 2020-08-05 | — | — | EP | disclosed |
| WO-2018119357-A1 | COMPOUNDS AND METHODS FOR THE TARGETED DEGRADATION OF ENHANCER OF ZESTE HOMOLOG 2 POLYPEPTIDE | Arvinas, Inc. (US) | 2018-06-28 | — | — | WO | disclosed |