Methane

Methane

SCHEMBL2033946

C.CC(C)(C)C(C(=O)O)[C@@H](N)C(=O)O

nearest known ligand 0.52

Full drug profile on Sugi Atlas →

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
SLC7A5 Q01650 2/20 0.52
PTGS1 P23219 2/20 0.41
ALDH1A1 P00352 1/20 0.41
MAPT P10636 1/20 0.41
SLC1A2 P43004 3/20 0.39
SLC1A3 P43003 2/20 0.39
SLC1A1 P43005 2/20 0.39
USP2 O75604 1/20 0.32
SLCO1B1 Q9Y6L6 1/20 0.32
GRIK1 P39086 1/20 0.31
ACHE P22303 1/20 0.31
GLO1 Q04760 1/20 0.31
NR1I2 O75469 1/20 0.31
ADRA1A P35348 1/20 0.31
LMNA P02545 1/20 0.31
BLM P54132 1/20 0.31
TDP1 Q9NUW8 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Methane SCHEMBL2032537 1.00 SLC7A5 (0.52) SLC7A5PTGS1ALDH1A1MAPTSLC1A2
SCHEMBL4441664 0.97 SLC7A5 (0.55) SLC7A5PTGS1ALDH1A1MAPTSLC1A2
SCHEMBL3891579 0.97 SLC7A5 (0.55) SLC7A5PTGS1ALDH1A1MAPTSLC1A2
SCHEMBL7400616 0.81 SLC7A5 (0.48) SLC7A5PTGS1ALDH1A1MAPTSLC1A2
Hydrochloric Acid SCHEMBL3471978 0.79 SLC7A5 (0.46) SLC7A5PTGS1ALDH1A1MAPTSLC1A2
SCHEMBL1604917 0.78 ALDH1A1 (0.39) SLC7A5PTGS1ALDH1A1MAPTADRA1A
SCHEMBL2059189 0.78 SLC7A5 (0.39) SLC7A5PTGS1ALDH1A1MAPTSLC1A2
SCHEMBL2059192 0.78 SLC7A5 (0.44) SLC7A5PTGS1ALDH1A1MAPTSLC1A2
SCHEMBL14975419 0.77 SLC7A5 (0.55) SLC7A5PTGS1ALDH1A1MAPTSLC1A2
SCHEMBL6974551 0.77 SLC7A5 (0.48) SLC7A5PTGS1ALDH1A1MAPTSLC1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10633630-B2 Acceleration of Mycobacterium growth ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB) 2020-04-28 US disclosed
EP-3158053-B1 ACCELERATION OF MYCOBACTERIUM GROWTH ST GEORGES HOSPITAL MEDICAL SCHOOL (GB) 2019-03-13 EP disclosed
US-9707282-B2 Small cationic antimicrobial peptides THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2017-07-18 US disclosed
US-20170121672-A1 ACCELERATION OF MYCOBACTERIUM GROWTH ST GEORGE'S HOSPITAL MEDICAL SCHOOL (GB) 2017-05-04 US disclosed
US-20150315240-A1 SMALL CATIONIC ANTIMICROBIAL PEPTIDES THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2015-11-05 US disclosed
EP-2061886-B1 Small cationic immunomodulatory peptides UNIV BRITISH COLUMBIA (CA) 2014-05-07 EP disclosed
US-8343475-B2 Small cationic antimicrobial peptides THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2013-01-01 US disclosed
US-20110236429-A1 Small Cationic Antimicrobial Peptides THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2011-09-29 US disclosed
US-20110150917-A1 Small Cationic Antimicrobial Peptides THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2011-06-23 US disclosed
EP-2061886-A1 SMALL CATIONIC ANTIMICROBIAL PEPTIDES The University of British Columbia (CA) 2009-05-27 EP disclosed
WO-2008151434-A1 SMALL CATIONIC ANTIMICROBIAL PEPTIDES THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2008-12-18 WO disclosed
WO-2008022444-A1 SMALL CATIONIC ANTIMICROBIAL PEPTIDES THE UNIVERSITY OF BRITISH COLUMBIA (CA) 2008-02-28 WO disclosed