Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | MAP3K12 | Q12852 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 1/20 | 0.31 |
| ▸ | BRAF | P15056 | 1/20 | 0.31 |
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.31 |
| ▸ | KIF18A | Q8NI77 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26381269 | 0.75 | KMT2A (0.62) | AKT1KMT2ACYP1A2CYP2D6MAPT | |
| SCHEMBL18399228 | 0.75 | PIK3CD (0.44) | AKT1KMT2ACYP1A2CYP2D6MAPT | |
| SCHEMBL21796865 | 0.75 | PIK3CD (0.44) | AKT1KMT2ACYP1A2CYP2D6MAPT | |
| SCHEMBL18398940 | 0.75 | PIK3CD (0.44) | AKT1KMT2ACYP1A2CYP2D6MAPT | |
| SCHEMBL16224484 | 0.74 | MAP3K12 (0.33) | MAP3K12 | |
| SCHEMBL22098492 | 0.73 | AKT1 (0.41) | AKT1KMT2ACYP1A2CYP2D6MAPT | |
| SCHEMBL22050881 | 0.72 | AKT1 (0.38) | AKT1KMT2ACYP1A2CYP2D6MAPT | |
| SCHEMBL17510275 | 0.72 | MAP3K12 (0.56) | MAP3K12 | |
| SCHEMBL22052409 | 0.65 | MAP3K12 (0.36) | AKT1KMT2AMAP3K12LRRK2SCN9A | |
| SCHEMBL22556086 | 0.65 | FPR2 (0.41) | AKT1CYP1A2MAPTPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10010549-B2 | Biheteroaryl compounds and uses thereof | GENENTECH, INC. (US) | 2018-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10010549-B2 | Biheteroaryl compounds and uses thereof | BCHE, SNCA, HAX1 | AKT1 2670/4885KMT2A 2566/4885CYP1A2 71/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.