Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLTP | P55058 | 8/20 | 0.48 |
| ▸ | TOP1 | P11387 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 3/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | RRM1 | P23921 | 1/20 | 0.40 |
| ▸ | RRM2B | Q7LG56 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20343837 | 0.88 | PLTP (0.48) | PLTPTOP1SMN1; SMN2KMT2AHPGD | |
| Coh-29 SCHEMBL10036527 | 0.80 | PLTP (0.61) | PLTPTOP1SMN1; SMN2KMT2AHPGD | |
| Coh-29 SCHEMBL31436912 | 0.80 | PLTP (0.61) | PLTPTOP1SMN1; SMN2KMT2AHPGD | |
| Coh-29 SCHEMBL29424344 | 0.80 | PLTP (0.61) | PLTPTOP1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL12940263 | 0.75 | PLTP (0.59) | PLTPTOP1SMN1; SMN2KMT2AHPGD | |
| SCHEMBL235132 | 0.69 | ADORA2A (0.76) | SMN1; SMN2KMT2AHPGDMAPTADORA3 | |
| SCHEMBL2753880 | 0.68 | SMN1; SMN2 (0.59) | SMN1; SMN2KMT2AHPGDMAPTADORA3 | |
| SCHEMBL10002071 | 0.68 | PLTP (0.63) | PLTPTOP1MAPTRRM1RRM2B | |
| SCHEMBL2753996 | 0.66 | ADORA1 (0.76) | SMN1; SMN2KMT2AHPGDMAPTADORA3 | |
| SCHEMBL235268 | 0.66 | ADORA3 (0.76) | SMN1; SMN2KMT2AHPGDMAPTADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2809662-B1 | RIBONUCLEOTIDE REDUCTASE INHIBITORS AND METHODS OF USE | HOPE CITY (US) | 2018-07-04 | — | — | EP | disclosed |