Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.80 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | THRB | P10828 | 1/20 | 0.58 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | CPT2 | P23786 | 1/20 | 0.51 |
| ▸ | CPT1A | P50416 | 1/20 | 0.51 |
| ▸ | CPT1B | Q92523 | 1/20 | 0.51 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | P2RY14 | Q15391 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1899756 | 0.89 | MEN1 (1.00) | MEN1KMT2AAURKARPS6KB1NPSR1 | |
| SCHEMBL1902344 | 0.89 | MEN1 (0.78) | MEN1KMT2AAURKARPS6KB1NPSR1 | |
| SCHEMBL20344448 | 0.83 | KMT2A (0.69) | MEN1KMT2AAURKARPS6KB1NPSR1 | |
| SCHEMBL29699759 | 0.82 | MEN1 (0.79) | MEN1KMT2AAURKARPS6KB1NPSR1 | |
| SCHEMBL7744403 | 0.81 | MEN1 (0.66) | MEN1KMT2AAURKARPS6KB1NPSR1 | |
| 4-Bromoaniline SCHEMBL7739202 | 0.79 | MEN1 (0.80) | MEN1KMT2AAURKARPS6KB1NPSR1 | |
| SCHEMBL3095032 | 0.78 | KMT2A (0.62) | MEN1KMT2ATHRBNPSR1MAPT | |
| SCHEMBL7744713 | 0.78 | KMT2A (0.62) | MEN1KMT2AAURKARPS6KB1NPSR1 | |
| SCHEMBL2077298 | 0.78 | MEN1 (0.62) | MEN1KMT2APTGER1P2RY14HDAC3 | |
| SCHEMBL3097099 | 0.78 | GAA (0.63) | MEN1KMT2ANPSR1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1252156-B1 | BLOCKADE OF VOLTAGE DEPENDENT SODIUM CHANNELS | UCL BUSINESS PLC (GB) | 2011-05-04 | — | — | EP | disclosed |