Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 6/20 | 0.53 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.49 |
| ▸ | XIAP | P98170 | 8/20 | 0.47 |
| ▸ | PYGL | P06737 | 1/20 | 0.45 |
| ▸ | PYGM | P11217 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MME | P08473 | 2/20 | 0.42 |
| ▸ | ACE | P12821 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31655855 | 0.85 | RIPK1 (0.60) | RIPK1SCN9AXIAPPYGLPYGM | |
| SCHEMBL20344528 | 0.83 | RIPK1 (0.57) | RIPK1 | |
| SCHEMBL31655974 | 0.77 | RIPK1 (0.58) | RIPK1SCN9AXIAPPYGLPYGM | |
| SCHEMBL3924251 | 0.75 | RIPK1 (0.63) | RIPK1SCN9AXIAPPYGLPYGM | |
| SCHEMBL4218830 | 0.75 | RIPK1 (0.63) | RIPK1SCN9AXIAPPYGLPYGM | |
| SCHEMBL14376829 | 0.75 | RIPK1 (0.60) | RIPK1SCN9AXIAPPYGLPYGM | |
| SCHEMBL17312498 | 0.71 | RIPK1 (0.66) | RIPK1SCN9APYGLPYGM | |
| SCHEMBL17312496 | 0.71 | RIPK1 (0.66) | RIPK1SCN9APYGLPYGM | |
| SCHEMBL19017810 | 0.70 | ACHE (0.43) | — | |
| SCHEMBL17312552 | 0.70 | RIPK1 (0.77) | RIPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3342771-B1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GLAXOSMITHKLINE IP DEV LTD (GB) | 2020-11-25 | — | — | EP | disclosed |
| EP-3508484-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Limited (GB) | 2019-07-10 | — | — | EP | disclosed |
| EP-3342771-A1 | HETEROCYCLIC AMIDES AS KINASE INHIBITORS | GlaxoSmithKline Intellectual Property Development Ltd (GB) | 2018-07-04 | — | — | EP | disclosed |